SRG3 interacts directly with the major components of the SWI/SNF chromatin remodeling complex and protects them from proteasomal degradation
DC Field | Value | Language |
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dc.contributor.author | Sohn, Dong H. | - |
dc.contributor.author | Lee, Kyoo Y. | - |
dc.contributor.author | Lee, Changjin | - |
dc.contributor.author | Oh, Jaehak | - |
dc.contributor.author | Chung, Heekyoung | - |
dc.contributor.author | Jeon, Sung H. | - |
dc.contributor.author | Seong, Rho H. | - |
dc.date.accessioned | 2022-12-21T08:50:15Z | - |
dc.date.available | 2022-12-21T08:50:15Z | - |
dc.date.created | 2022-08-26 | - |
dc.date.issued | 2007-04 | - |
dc.identifier.issn | 0021-9258 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/180287 | - |
dc.description.abstract | The mammalian SWI/SNF complex is an evolutionarily conserved ATP-dependent chromatin remodeling complex that consists of nine or more components. SRG3, a murine homologue of yeast SWI3, Drosophila MOIRA, and human BAF155, is a core component of the murine SWI/SNF complex required for the regulation of transcriptional processes associated with development, cellular differentiation, and proliferation. Here we report that SRG3 interacts directly with other components of the mammalian SWI/SNF complex such as SNF5, BRG1, and BAF60a. The SWIRM domain and the SANT domain were required for SRG3-SNF5 and SRG3-BRG1 interactions, respectively. In addition, SRG3 stabilized SNF5, BRG1, and BAF60a by attenuating their proteasomal degradation, suggesting its general role in the stabilization of the SWI/SNF complex. Such a stabilization effect of SRG3 was not only observed in the in vitro cell system, but also in cells isolated from SRG3 transgenic mice or knock-out mice haploinsufficient for the Srg3 gene. Taken together, these results suggest the critical role of SRG3 in the post-transcriptional stabilization of the major components of the SWI/SNF complex. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC | - |
dc.title | SRG3 interacts directly with the major components of the SWI/SNF chromatin remodeling complex and protects them from proteasomal degradation | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Chung, Heekyoung | - |
dc.identifier.doi | 10.1074/jbc.M610563200 | - |
dc.identifier.scopusid | 2-s2.0-34249782070 | - |
dc.identifier.wosid | 000245941000055 | - |
dc.identifier.bibliographicCitation | JOURNAL OF BIOLOGICAL CHEMISTRY, v.282, no.14, pp.10614 - 10624 | - |
dc.relation.isPartOf | JOURNAL OF BIOLOGICAL CHEMISTRY | - |
dc.citation.title | JOURNAL OF BIOLOGICAL CHEMISTRY | - |
dc.citation.volume | 282 | - |
dc.citation.number | 14 | - |
dc.citation.startPage | 10614 | - |
dc.citation.endPage | 10624 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.subject.keywordPlus | GLUCOCORTICOID-INDUCED APOPTOSIS | - |
dc.subject.keywordPlus | RECEPTOR-DEPENDENT TRANSCRIPTION | - |
dc.subject.keywordPlus | SACCHAROMYCES-CEREVISIAE | - |
dc.subject.keywordPlus | SWIRM DOMAIN | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | PROTEINS | - |
dc.subject.keywordPlus | HOMOLOG | - |
dc.subject.keywordPlus | BINDING | - |
dc.subject.keywordPlus | DNA | - |
dc.subject.keywordPlus | TRANSACTIVATION | - |
dc.identifier.url | https://www.sciencedirect.com/science/article/pii/S0021925819577365?via%3Dihub | - |
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