Nurr1 과발현에 의한 도파민신경세포 기능향사에 미치는 Mash1의 역할

Abstract

hi vitro expanded CNS precursors provide a potentially unlimited source of dopamine(DA) neurons for the experimental treatment in Parkinson's disease. But all efficient DA differentiation from CNS precursors ill vitro is limited to mesencephalic precursors isolated from early embryonic ages (embryonic day 11.5 similar to 12.5). Recently demonstrated that Nurr1, a steroid-type orphan nuclear receptor, sufficiently derives neural precursor cells, isolated from rat embryonic brains, to differentiate toward DA neurons. Nurr1-induced DA neurons, however, were less mature in their neuronal morphology and pre-synaptic functions ill vitro and do not elicit behavioral recovery upon transplantation into a rodent model of Parkinson's disease. In this study, genetic manipulation of Mash1 in the Nurr1-DA cells contributes to the acquisition of the functions to restore behavioral deficits in Parkinsonian rats, thereby these cells become a potential cell source for Parkinson's cell therapy.