IL-18 is induced and IL-18 receptor alpha plays a critical role in the pathogenesis of cigarette emphysema and inflammation
DC Field | Value | Language |
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dc.contributor.author | Kang, Min-Jong | - |
dc.contributor.author | Homer, Robert J. | - |
dc.contributor.author | Gallo, Amy | - |
dc.contributor.author | Lee, Chun Geun | - |
dc.contributor.author | Crothers, Kristina A. | - |
dc.contributor.author | Cho, Soo Jung | - |
dc.contributor.author | Rochester, Carolyn | - |
dc.contributor.author | Cain, Hilary | - |
dc.contributor.author | Chupp, Geoffrey | - |
dc.contributor.author | Yoon, Ho Joo | - |
dc.contributor.author | Elias, Jack A. | - |
dc.date.accessioned | 2022-12-21T09:11:36Z | - |
dc.date.available | 2022-12-21T09:11:36Z | - |
dc.date.created | 2022-08-26 | - |
dc.date.issued | 2007-02 | - |
dc.identifier.issn | 0022-1767 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/180489 | - |
dc.description.abstract | Th1 inflammation and remodeling characterized by local tissue destruction coexist in pulmonary emphysema and other diseases. To test the hypothesis that IL-18 plays an important role in these responses, we characterized the regulation of IL-18 in lungs from cigarette smoke (CS) and room air-exposed mice and characterized the effects of CS in wild-type mice and mice with null mutations of IL-18R alpha (IL-18R alpha(-/-)). CS was a potent stimulator and activator of IL-18 and caspases 1 and 11. In addition, although CS caused inflammation and emphysema in wild-type mice, both of these responses were significantly decreased in IL-18Ra-/- animals. CS also induced epithelial apoptosis, activated effector caspases and stimulated proteases and chemokines via IL-18R alpha-dependent pathways. Importantly, the levels of IL-18 and its targets, cathepsins S and B, were increased in pulmonary macrophages from smokers and patients with chronic obstructive lung disease. Elevated levels of circulating IL-18 were also seen in patients with chronic obstructive lung disease. These studies demonstrate that IL-18 and the IL-18 pathway are activated in CS-exposed mice and man. They also demonstrate, in a murine modeling system, that IL-18R signaling plays a critical role in the pathogenesis of CS-induced inflammation and emphysema. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | AMER ASSOC IMMUNOLOGISTS | - |
dc.title | IL-18 is induced and IL-18 receptor alpha plays a critical role in the pathogenesis of cigarette emphysema and inflammation | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Yoon, Ho Joo | - |
dc.identifier.doi | 10.4049/jimmunol.178.3.1948 | - |
dc.identifier.scopusid | 2-s2.0-33846505023 | - |
dc.identifier.wosid | 000243820900081 | - |
dc.identifier.bibliographicCitation | JOURNAL OF IMMUNOLOGY, v.178, no.3, pp.1948 - 1959 | - |
dc.relation.isPartOf | JOURNAL OF IMMUNOLOGY | - |
dc.citation.title | JOURNAL OF IMMUNOLOGY | - |
dc.citation.volume | 178 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 1948 | - |
dc.citation.endPage | 1959 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Immunology | - |
dc.relation.journalWebOfScienceCategory | Immunology | - |
dc.subject.keywordPlus | OBSTRUCTIVE PULMONARY-DISEASE | - |
dc.subject.keywordPlus | SMOKE-INDUCED EMPHYSEMA | - |
dc.subject.keywordPlus | CD8(+) T-LYMPHOCYTES | - |
dc.subject.keywordPlus | CHRONIC-BRONCHITIS | - |
dc.subject.keywordPlus | INTERFERON-GAMMA | - |
dc.subject.keywordPlus | CELL APOPTOSIS | - |
dc.subject.keywordPlus | UP-REGULATION | - |
dc.subject.keywordPlus | IFN-GAMMA | - |
dc.subject.keywordPlus | MATRIX METALLOPROTEINASES | - |
dc.subject.keywordPlus | INCREASED EXPRESSION | - |
dc.identifier.url | https://www.jimmunol.org/content/178/3/1948 | - |
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