Significant association of Fc epsilon RI alpha promoter polymorphisms with aspirin-intolerant chronic urticaria
DC Field | Value | Language |
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dc.contributor.author | Bae, Jin Sik | - |
dc.contributor.author | Kim, Seung Hyun | - |
dc.contributor.author | Ye, Young Min | - |
dc.contributor.author | Yoon, Ho Joo | - |
dc.contributor.author | Suh, Chang Hee | - |
dc.contributor.author | Nahm, Dong Ho | - |
dc.contributor.author | Park, Hae-Sim | - |
dc.date.accessioned | 2022-12-21T09:12:02Z | - |
dc.date.available | 2022-12-21T09:12:02Z | - |
dc.date.created | 2022-08-26 | - |
dc.date.issued | 2007-02 | - |
dc.identifier.issn | 0091-6749 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/180492 | - |
dc.description.abstract | Background: Although the mechanism that underlies aspirin hypersensitivity is not completely understood, an IgE-mediated response was reported for a patient with aspirin-intolerant chronic urticaria (AICU). Objective: We investigated whether genetic polymorphisms on the a-chain of the high-affinity IgE receptor (Fc epsilon RI alpha) gene were associated with the AICU phenotype. Methods: We genotyped 2 promoter polymorphisms (-344C > T and -95T > C) of Fc epsilon RI alpha gene in the Korean population, and the functional effect of the -344C > T polymorphism was analyzed by using a luciferase reporter assay and an electrophoretic mobility shift assay. Results: The rare allele frequency of the -344C > T polymorphism was significantly higher in the patients with AICU compared with the other subjects (P = .008 for AICU vs aspirin-tolerant chronic urticaria; P = .03 for AICU vs controls). This polymorphism was also significantly associated with total serum IgE concentrations and a higher rate of atopy in the patients with AICU (P = .01 and .05, respectively). The reporter plasmid that carried the -344T allele exhibited significantly higher promoter activity in a rat mast cell line (RBL-2H3) compared with the promoter activity of the -344C allele (P < .001). We found that transcription factor Myc-associated zinc finger protein preferentially bound the -344C promoter. Moreover, patients with AICU with the heterozygous CT genotype of the -344C > T polymorphism exhibited greater anti-IgE-mediated histamine release compared with those with the homozygous CC genotype. Conclusion: These results suggest that the -344C > T polymorphism of the Fc epsilon RI alpha promoter may be associated with increased expression of Fc epsilon RI alpha on mast cells and enhanced release of histamine. Clinical implications: The Fc epsilon RI alpha -344C > T polymorphism may contribute to the development of AICU. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | MOSBY-ELSEVIER | - |
dc.title | Significant association of Fc epsilon RI alpha promoter polymorphisms with aspirin-intolerant chronic urticaria | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Yoon, Ho Joo | - |
dc.identifier.doi | 10.1016/j.jaci.2006.10.006 | - |
dc.identifier.scopusid | 2-s2.0-33846850455 | - |
dc.identifier.wosid | 000244327900025 | - |
dc.identifier.bibliographicCitation | JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, v.119, no.2, pp.449 - 456 | - |
dc.relation.isPartOf | JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY | - |
dc.citation.title | JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY | - |
dc.citation.volume | 119 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 449 | - |
dc.citation.endPage | 456 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Allergy | - |
dc.relation.journalResearchArea | Immunology | - |
dc.relation.journalWebOfScienceCategory | Allergy | - |
dc.relation.journalWebOfScienceCategory | Immunology | - |
dc.subject.keywordPlus | IMMUNOGLOBULIN-E | - |
dc.subject.keywordPlus | MAST-CELLS | - |
dc.subject.keywordPlus | CHAIN GENE | - |
dc.subject.keywordPlus | IGE | - |
dc.subject.keywordPlus | RECEPTOR | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | MAZ | - |
dc.subject.keywordPlus | HISTAMINE | - |
dc.subject.keywordPlus | SP1 | - |
dc.subject.keywordPlus | SENSITIVITY | - |
dc.subject.keywordAuthor | aspirin | - |
dc.subject.keywordAuthor | hypersensitivity | - |
dc.subject.keywordAuthor | chronic urticaria | - |
dc.subject.keywordAuthor | high-affinity IgE receptor | - |
dc.subject.keywordAuthor | genetic polymorphism | - |
dc.identifier.url | https://www.sciencedirect.com/science/article/pii/S0091674906021208?via%3Dihub | - |
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