Cyclooxygenase-2 polymorphisms and risk of systemic lupus erythematosus in Koreans
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Her, Min-Young | - |
dc.contributor.author | El-Sohemy, Ahmed | - |
dc.contributor.author | Cornelis, Marilyn C. | - |
dc.contributor.author | Kim, Tae-Hwan | - |
dc.contributor.author | Bae, Sang-Cheol | - |
dc.date.accessioned | 2022-12-21T09:54:00Z | - |
dc.date.available | 2022-12-21T09:54:00Z | - |
dc.date.created | 2022-09-16 | - |
dc.date.issued | 2006-11 | - |
dc.identifier.issn | 0172-8172 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/180769 | - |
dc.description.abstract | Cyclooxygenase-2 (COX-2) is a key regulatory enzyme in the synthesis of prostanoids associated with trauma and inflammation. Upregulation of COX-2 in human lupus T cells resists anergy and apotosis. We investigated the COX-2 gene for functional variants that may influence susceptibility, clinical outcomes and severity of systemic lupus erythematosus (SLE) in a Korean population. The study included 345 patients with SLE and 400 unrelated healthy controls. Genotyping for the -765G -> C polymorphism of COX-2 was performed by PCR - RFLP analysis. No difference in the distribution of the genotype frequencies between patients and controls was found. COX-2 genotypes were not associated with clinical features except hematologic abnormalities and anti-RNP antibody. We did not detect any association between COX-2 genotype and disease severity in SLE patients. These results suggest that the -765G -> C polymorphism of COX-2 does not play a significant role in the development of SLE in a Korean population. A possible protective effect of the low activity C allele against the production of anti-RNP antibodies merits further investigation. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | SPRINGER | - |
dc.title | Cyclooxygenase-2 polymorphisms and risk of systemic lupus erythematosus in Koreans | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Tae-Hwan | - |
dc.contributor.affiliatedAuthor | Bae, Sang-Cheol | - |
dc.identifier.doi | 10.1007/s00296-006-0162-z | - |
dc.identifier.scopusid | 2-s2.0-33750485335 | - |
dc.identifier.wosid | 000241580800001 | - |
dc.identifier.bibliographicCitation | RHEUMATOLOGY INTERNATIONAL, v.27, no.1, pp.1 - 5 | - |
dc.relation.isPartOf | RHEUMATOLOGY INTERNATIONAL | - |
dc.citation.title | RHEUMATOLOGY INTERNATIONAL | - |
dc.citation.volume | 27 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 1 | - |
dc.citation.endPage | 5 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Rheumatology | - |
dc.relation.journalWebOfScienceCategory | Rheumatology | - |
dc.subject.keywordPlus | T-CELLS | - |
dc.subject.keywordPlus | GENE | - |
dc.subject.keywordPlus | NEPHRITIS | - |
dc.subject.keywordPlus | DEATH | - |
dc.subject.keywordAuthor | cyclooxygenase-2 | - |
dc.subject.keywordAuthor | systemic lupus erythematosus | - |
dc.subject.keywordAuthor | polymorphism | - |
dc.identifier.url | https://link.springer.com/article/10.1007/s00296-006-0162-z | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
222, Wangsimni-ro, Seongdong-gu, Seoul, 04763, Korea+82-2-2220-1365
COPYRIGHT © 2021 HANYANG UNIVERSITY.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.