Optimal switching in structured treatment interruption for HIV therapy

Abstract

This paper proposes 'optimal switching control during structured treatment interruption, which switches RTI and PI to reduce medication and establish long-term immune response against HIV. The proposed method is compared with 'optimized STI' through numerical simulation. The proposed method results in a more rapid increase of CTLp, and thus total drug intake and the therapy period are reduced. HIV treatment simulation results are analyzed in terms of controllability. Due to the effect of PI, 'optimal switching control during STI' can achieve greater controllability more quickly than 'optimized STI'.