열공성 경색 환자에서 경사에코 자기공명영상상 보이는 미세출혈과 Matrix Metalloproteinases-9과의 관계
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 박창윤 | - |
dc.contributor.author | 김현영 | - |
dc.contributor.author | 고성호 | - |
dc.contributor.author | 이규용 | - |
dc.contributor.author | 이영주 | - |
dc.contributor.author | 김주한 | - |
dc.contributor.author | 김승현 | - |
dc.contributor.author | 구대림 | - |
dc.date.accessioned | 2022-12-21T10:41:23Z | - |
dc.date.available | 2022-12-21T10:41:23Z | - |
dc.date.created | 2022-09-19 | - |
dc.date.issued | 2006-08 | - |
dc.identifier.issn | 1225-7044 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/181112 | - |
dc.description.abstract | Background: Hypointense cerebral lesions on T2*-weighted gradient-echo MRI (GRE) have been known to be related with microbleeds or advanced microangiopathy with potential for further bleeding. It has also been suggested that matrix metalloproteinases (MMPs) may play a role in blood brain barrier disruption, edema formation and hemorrhagic transformation. In this study, we investigated the relationship between microbleeds detected by GRE, MMPs and neurological worsening in acute lacunar infarctions. Methods: Eighty-eight patients with acute lacunar infarctions, defined by TOAST classification, were included. GRE (1.5T, TR 500 ms TE 15 ms) was performed within 48 hours after stroke symptom onset. MMPs were measured by standard quantitative sandwich enzyme-linked immunosorbent assays (ELISA). Clinical characteristics, neurologic scale and MMP-9 levels were compared between groups with or without hypointense lesions in GRE (microbleeds). Neurological worsening was defined as deterioration from baseline in the score on the NIHSS by one or more points 14 days after the onset of a lacunar infarction. Results: Eleven of 88 patients (12.5%) undergoing GRE demonstrated evidence of microbleeds in the ischemic region. In the groups with microbleeds, the ESR level (p=0.048) and MMP-9 activity (p=0.001) were significantly increased, and neurological worsening was more prominent (p=0.018). Conclusions: This study suggests that microbleeds detected by GRE are related with elevated MMP-9 and neurological worsening. Therefore, the finding of microbleeds in GRE, increased MMP-9 activity and elevated ESR level might be useful factors for predicting the progression of acute lacunar infarctions. | - |
dc.language | 한국어 | - |
dc.language.iso | ko | - |
dc.publisher | 대한신경과학회 | - |
dc.title | 열공성 경색 환자에서 경사에코 자기공명영상상 보이는 미세출혈과 Matrix Metalloproteinases-9과의 관계 | - |
dc.title.alternative | The Relationship of Matrix Metalloproteinase-9 and Microbleeds on T2*-Weighted Gradient-Echo MRI in Acute Lacunar Infarction | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | 김현영 | - |
dc.contributor.affiliatedAuthor | 이규용 | - |
dc.contributor.affiliatedAuthor | 이영주 | - |
dc.contributor.affiliatedAuthor | 김승현 | - |
dc.identifier.bibliographicCitation | 대한신경과학회지, v.24, no.4, pp.311 - 317 | - |
dc.relation.isPartOf | 대한신경과학회지 | - |
dc.citation.title | 대한신경과학회지 | - |
dc.citation.volume | 24 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 311 | - |
dc.citation.endPage | 317 | - |
dc.type.rims | ART | - |
dc.identifier.kciid | ART001121307 | - |
dc.description.journalClass | 2 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | kci | - |
dc.subject.keywordAuthor | Microbleeds | - |
dc.subject.keywordAuthor | Gradient echo MRI | - |
dc.subject.keywordAuthor | MMP-9 | - |
dc.subject.keywordAuthor | Lacunar stroke | - |
dc.subject.keywordAuthor | Microbleeds | - |
dc.subject.keywordAuthor | Gradient echo MRI | - |
dc.subject.keywordAuthor | MMP-9 | - |
dc.subject.keywordAuthor | Lacunar stroke | - |
dc.identifier.url | https://www.kci.go.kr/kciportal/ci/sereArticleSearch/ciSereArtiView.kci?sereArticleSearchBean.artiId=ART001121307 | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
222, Wangsimni-ro, Seongdong-gu, Seoul, 04763, Korea+82-2-2220-1365
COPYRIGHT © 2021 HANYANG UNIVERSITY.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.