Supervised membrane swimming: small G-protein lifeguards regulate PIPK signalling and monitor intracellular PtdIns(4,5)P-2 pools
DC Field | Value | Language |
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dc.contributor.author | Santarius, Megan | - |
dc.contributor.author | Lee, Chang Ho | - |
dc.contributor.author | Anderson, Richard A. | - |
dc.date.accessioned | 2022-12-21T10:49:29Z | - |
dc.date.available | 2022-12-21T10:49:29Z | - |
dc.date.created | 2022-09-16 | - |
dc.date.issued | 2006-08 | - |
dc.identifier.issn | 0264-6021 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/181182 | - |
dc.description.abstract | Regulation of PIPK (phosphatidylinositol phosphate kinase) and PtdIns(4,5)P-2 signalling by small G-proteins and their effectors is key to many biological functions. Through selective recruitment and activation of different PIPK isoforms, small G-proteins such as Rho, Rac and Cdc42 modulate actin dynamics and cytoskeleton-dependent cellular events in response to extracellular signalling. These activities affect a number of processes, including endocytosis, bacterial penetration into host cells and cytolytic granule-mediated targeted cell killing. Small G-proteins and their modulators are also regulated by phosphoinositides through translocation and conformational changes. Arf family small G-proteins act at multiple sites as regulators of membrane trafficking and actin cytoskeletal remodelling, and regulate a feedback loop comprising phospholipase D, phosphatidic acid, PIPKs and PtdIns(4,5)P-2. contributing to enhancement of PtdIns(4,5)P-2-mediated cellular events and receptor signalling. Na+, Kir (inwardly rectifying K+), Ca2+ and TRP (transient receptor potential) ion channels are regulated by small G-proteins and membrane pools of PtdIns(4,5)P-2. Yeast phosphatidylinositol 4-phosphate 5-kinases Mss4 and Its3 are involved in resistance against disturbance of sphingolipid biosynthesis and maintenance of cell integrity through the synthesis of PtdIns(4,5)P-2 and downstream signalling through the Rom2/Rho2 and Rgf1/Rho pathways. Here, we review models for regulated intracellular targeting of PIPKs by small G-proteins and other modulators in response to extracellular signalling. We also describe the spatial and temporal cross-regulation of PIPKs and small G-proteins that is critical for a number of cellular functions. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | PORTLAND PRESS LTD | - |
dc.title | Supervised membrane swimming: small G-protein lifeguards regulate PIPK signalling and monitor intracellular PtdIns(4,5)P-2 pools | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Lee, Chang Ho | - |
dc.identifier.doi | 10.1042/BJ20060565 | - |
dc.identifier.scopusid | 2-s2.0-33747184318 | - |
dc.identifier.wosid | 000239836100001 | - |
dc.identifier.bibliographicCitation | BIOCHEMICAL JOURNAL, v.398, pp.1 - 13 | - |
dc.relation.isPartOf | BIOCHEMICAL JOURNAL | - |
dc.citation.title | BIOCHEMICAL JOURNAL | - |
dc.citation.volume | 398 | - |
dc.citation.startPage | 1 | - |
dc.citation.endPage | 13 | - |
dc.type.rims | ART | - |
dc.type.docType | Review | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.subject.keywordPlus | PHOSPHATIDYLINOSITOL 4-PHOSPHATE 5-KINASE | - |
dc.subject.keywordPlus | ACTIN STRESS FIBERS | - |
dc.subject.keywordPlus | SMALL GTPASE RHO | - |
dc.subject.keywordPlus | ADP-RIBOSYLATION FACTOR-1 | - |
dc.subject.keywordPlus | EPITHELIAL NA+ CHANNEL | - |
dc.subject.keywordPlus | PHOSPHOLIPASE-D | - |
dc.subject.keywordPlus | PHOSPHATE KINASE | - |
dc.subject.keywordPlus | CELL-WALL | - |
dc.subject.keywordPlus | SCHIZOSACCHAROMYCES-POMBE | - |
dc.subject.keywordPlus | PLASMA-MEMBRANE | - |
dc.subject.keywordAuthor | ADP-ribosylation factor 1/6 (Arf1/Arf6) | - |
dc.subject.keywordAuthor | phosphatidylinositol phosphate kinase (PIPK) | - |
dc.subject.keywordAuthor | PtdIns(4,5)P-2 | - |
dc.subject.keywordAuthor | phosphatidic acid | - |
dc.subject.keywordAuthor | Rho/Rac/Cdc42 | - |
dc.subject.keywordAuthor | small G-protein | - |
dc.identifier.url | https://portlandpress.com/biochemj/article/398/1/1/41551/Supervised-membrane-swimming-small-G-protein0 | - |
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