Prevention of withdrawal associated with the injection of rocuronium in adults and children
- Authors
- Kim, Kyo S.; Kim, Young S.; Jeon, Woo Jae; Yeom, Jong Hun
- Issue Date
- Aug-2006
- Publisher
- ELSEVIER SCIENCE INC
- Keywords
- anesthesia, general; movement, injection; neuromuscular blocking agent : rocuromum
- Citation
- JOURNAL OF CLINICAL ANESTHESIA, v.18, no.5, pp.334 - 338
- Indexed
- SCIE
SCOPUS
- Journal Title
- JOURNAL OF CLINICAL ANESTHESIA
- Volume
- 18
- Number
- 5
- Start Page
- 334
- End Page
- 338
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/181189
- DOI
- 10.1016/j.jclinane.2005.12.001
- ISSN
- 0952-8180
- Abstract
- Study Objective: To determine which technique prevents the withdrawal associated with rocuronium administration in adults and children. Design: Blinded, randomized, prospective trial. Setting: This study was set at an inpatient anesthesia in a university teaching hospital. Patients: 200 adult patients (aged 19-63 years) and 150 children (aged 2-9 years) undergoing elective surgery requiring endotracheal intubation. Interventions: Four groups in adult and 3 groups in children of 50 patients each were investigated. In adult study, control groups with free intravenous (IV) flow (C-F) or the occlusion of IV flow (C-O) received saline as the pretreatment of rocuronium; lidocaine groups with free IV flow (L-F) or the occlusion of IV flow (L-O) received lidocaine as the pretreatment of rocuronium, preceded by thiopental 5 seconds before. In children study, groups P and L received saline and lidocaine as the pretreatment of rocuronium, respectively, and group S received rocuronium mixed with sodium bicarbonate after the pretreatment of placebo preceded by thiopental. Measurements and Main Results: The patient's response to rocuronium injection was graded using a 4-point scale. The pH and osmolality of treatment solution were measured. The incidence of no movement after rocuronium was 96% in L-O, 46% in L-F, 26% in C-O, and 18% in C-F in adult and 96% in S, 58% in L, and 8% in P in children. Conclusions: Withdrawal after rocuronium can be eliminated by the pretreatment of lidocaine during the occlusion of the IV flow in adults and addition of sodium bicarbonate in children.
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