Interfering antiviral immunity: application, subversion, hope?
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Manjunath, N. | - |
dc.contributor.author | Kumar, Priti | - |
dc.contributor.author | Lee, Sang Kyung | - |
dc.contributor.author | Shankar, Premlata | - |
dc.date.accessioned | 2022-12-21T10:53:45Z | - |
dc.date.available | 2022-12-21T10:53:45Z | - |
dc.date.created | 2022-09-16 | - |
dc.date.issued | 2006-07 | - |
dc.identifier.issn | 1471-4906 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/181222 | - |
dc.description.abstract | RNA interference (RNAi), initially recognized as a natural antiviral mechanism in plants, has rapidly emerged as an invaluable tool to suppress gene expression in a sequence-specific manner in all organisms, including mammals. Its potential to inhibit the replication of a variety of viruses has been demonstrated in vitro and in vivo in mouse and monkey models. These results have generated profound interest in the use of this technology as a potential treatment strategy for viral infections for which vaccines and drugs are unavailable or inadequate. In this review, we discuss the progress made within the past 2-3 years towards harnessing the potential of RNAi for clinical application in viral infections and the hurdles that have yet to be overcome. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER SCI LTD | - |
dc.title | Interfering antiviral immunity: application, subversion, hope? | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Lee, Sang Kyung | - |
dc.identifier.doi | 10.1016/j.it.2006.05.006 | - |
dc.identifier.scopusid | 2-s2.0-33745495559 | - |
dc.identifier.wosid | 000239369400006 | - |
dc.identifier.bibliographicCitation | TRENDS IN IMMUNOLOGY, v.27, no.7, pp.328 - 335 | - |
dc.relation.isPartOf | TRENDS IN IMMUNOLOGY | - |
dc.citation.title | TRENDS IN IMMUNOLOGY | - |
dc.citation.volume | 27 | - |
dc.citation.number | 7 | - |
dc.citation.startPage | 328 | - |
dc.citation.endPage | 335 | - |
dc.type.rims | ART | - |
dc.type.docType | Review | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Immunology | - |
dc.relation.journalWebOfScienceCategory | Immunology | - |
dc.subject.keywordPlus | IMMUNODEFICIENCY-VIRUS TYPE-1 | - |
dc.subject.keywordPlus | DOUBLE-STRANDED-RNA | - |
dc.subject.keywordPlus | PRIMARY HEMATOPOIETIC-CELLS | - |
dc.subject.keywordPlus | LENTIVIRAL VECTOR DELIVERY | - |
dc.subject.keywordPlus | GENE-EXPRESSION | - |
dc.subject.keywordPlus | IN-VIVO | - |
dc.subject.keywordPlus | MAMMALIAN-CELLS | - |
dc.subject.keywordPlus | T-CELLS | - |
dc.subject.keywordPlus | MEDIATED DELIVERY | - |
dc.subject.keywordPlus | HIV-1 INFECTION | - |
dc.identifier.url | https://www.sciencedirect.com/science/article/pii/S1471490606001487?via%3Dihub | - |
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