Cyclooxygenase-2 genotype and rheumatoid arthritis
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, Kyu Hoon | - |
dc.contributor.author | Kim, Hee-Sang | - |
dc.contributor.author | El-Sohemy, Ahmed | - |
dc.contributor.author | Cornelis, Marilyn C. | - |
dc.contributor.author | Uhm, Wan-Sik | - |
dc.contributor.author | Bae, Sang-Cheol | - |
dc.date.accessioned | 2022-12-21T10:55:08Z | - |
dc.date.available | 2022-12-21T10:55:08Z | - |
dc.date.created | 2022-09-16 | - |
dc.date.issued | 2006-07 | - |
dc.identifier.issn | 0315-162X | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/181232 | - |
dc.description.abstract | Objective. To determine the association between cyclooxygenase-2 (COX-2) genotypes and risk and severity of rheumatoid arthritis (RA) in a Korean population. Methods. A total of 258 Korean patients with RA and 400 control subjects were recruited from Hanyang University Hospital. Subjects were genotyped for the -765G/C polymorphism of the COX-2 gene by RFLP-PCR analysis. Odds ratios (OR) and 95% confidence intervals (0) were calculated to estimate risk. Severity of RA was assessed by anatomical stage according to Steinbrocker. et al. Results. No association was observed between COX-2 genotype and risk or severity of RA. However, among those without the shared epitope (SE), carriers of the low activity C allele had a lower risk of RA and less severe form of RA than subjects with the GIG genotype. The OR (95% Q was 0.36 (0.14-0.95) for risk of RA and 0.04 (0.01-0.41) for seventy. Conclusion. These results suggest that COX-2 genotyping might be useful in predicting the risk and severity of RA in individuals without the SE. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | J RHEUMATOL PUBL CO | - |
dc.title | Cyclooxygenase-2 genotype and rheumatoid arthritis | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Lee, Kyu Hoon | - |
dc.contributor.affiliatedAuthor | Bae, Sang-Cheol | - |
dc.identifier.scopusid | 2-s2.0-33745783501 | - |
dc.identifier.wosid | 000238872000006 | - |
dc.identifier.bibliographicCitation | JOURNAL OF RHEUMATOLOGY, v.33, no.7, pp.1231 - 1234 | - |
dc.relation.isPartOf | JOURNAL OF RHEUMATOLOGY | - |
dc.citation.title | JOURNAL OF RHEUMATOLOGY | - |
dc.citation.volume | 33 | - |
dc.citation.number | 7 | - |
dc.citation.startPage | 1231 | - |
dc.citation.endPage | 1234 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Rheumatology | - |
dc.relation.journalWebOfScienceCategory | Rheumatology | - |
dc.subject.keywordPlus | INFLAMMATORY RESPONSE | - |
dc.subject.keywordPlus | PROMOTER VARIANT | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | DISEASE | - |
dc.subject.keywordPlus | COX-2 | - |
dc.subject.keywordPlus | OSTEOARTHRITIS | - |
dc.subject.keywordPlus | ASSOCIATION | - |
dc.subject.keywordPlus | INHIBITOR | - |
dc.subject.keywordPlus | SEVERITY | - |
dc.subject.keywordPlus | RISK | - |
dc.subject.keywordAuthor | polymorphism | - |
dc.subject.keywordAuthor | cyclooxygenase-2 | - |
dc.subject.keywordAuthor | shared epitope | - |
dc.subject.keywordAuthor | Korea | - |
dc.subject.keywordAuthor | rheumatoid arthritis | - |
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