흰쥐에서의 Dextran Sulfate Sodium-유발 궤양성 대장염에 대한 Curcumin의 효과

Abstract

Ulcerative colitis (UC), one of the inflammatory bowel diseases (IBD), tends to increase in Korea every year, but their causes and pathogenesis is still unknown. Sulfasalazine and corticosteroid are regularly used to treat IBD, but they have many side effects during long-term use and none therapeutic effect for some patients. So it is important to explore new agents that are more effective and have fewer side effects. Curcuma is the main component of turmeric, has anti-carcinogenic, anti-oxidative and anti- inflammatory activities. The aim of this study was to evaluate the effect of curcumin on UC induced by dextran sulfate sodium (2% DSS for 4 weeks) in the rat. The experiment animals were divided into four groups: control (normal), DDS-induced colitis rats, high-dose (100 mg/kg/day, po) and low dose (10 mg/kg/day, po)-treated groups that treated for 7 weeks during 4 weeks with 2% DDS and 3 weeks alone. We evaluated pathologically disease activity index (DAI) and the colon mucosa damage index (CMDI) and biochemically malondialdehyde (MDA), prostaglandin E2 (PGE2) in colon mucosa. The DAI and CDMI in DDS-induced colitis rats were more severe and the content of MDA and PGE2 level in DDS-induced rat were also higher than control and curcumin-treated rats, respectively. Curcumin may be alleviating some abnormality of disease index in a dose-depended manner. (Cancer Prevention Res 11, 137-143, 2006)