NF-kappa B activation pathway is essential for the chemokine expression in intestinal epithelial cells stimulated with Clostridium difficile toxin A
DC Field | Value | Language |
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dc.contributor.author | Kim, Jung Mogg | - |
dc.contributor.author | Lee, Jin-Young | - |
dc.contributor.author | Yoon, Young Mee | - |
dc.contributor.author | Oh, Yu Kyoung | - |
dc.contributor.author | Youn, Jeungyeun | - |
dc.contributor.author | Kim, Young-Jeon | - |
dc.date.accessioned | 2022-12-21T11:06:33Z | - |
dc.date.available | 2022-12-21T11:06:33Z | - |
dc.date.created | 2022-09-16 | - |
dc.date.issued | 2006-06 | - |
dc.identifier.issn | 0300-9475 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/181354 | - |
dc.description.abstract | Intestinal epithelial cells are known to upregulate the expression of several chemokines in response to stimulation with bacterial toxin. However, the cellular mechanisms of Clostridium difficile toxin A-induced mucosal inflammation have not yet been fully elucidated. In this study, we investigated whether nuclear factor-kappa B (NF-kappa B) could regulate chemokine expression in intestinal epithelial cells. Toxin A increased the levels of NF-kappa B complexes containing p65/p50 heterodimers and p65/p65 homodimers. Concurrently, toxin A decreased the levels of I kappa B alpha. Toxin A stimulation also increased the signals of phosphorylated I kappa B kinase (IKK)alpha/beta and NF-kappa B-inducing kinase (NIK). In the toxin A-stimulated HT-29 cells, the suppression of IKK or NIK inhibited the upregulation of downstream target genes of NF-kappa B such as IL-8 and monocytechemotactic protein (MCP)-1 and similarly, inhibition of NF-kappa B also downregulated the expression of IL-8, growth-related oncogene-alpha, and MCP-1. These results suggest that NF-kappa B signalling events may be involved in the inflammatory responses to toxin A produced by toxigenic C. difficile. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | WILEY | - |
dc.title | NF-kappa B activation pathway is essential for the chemokine expression in intestinal epithelial cells stimulated with Clostridium difficile toxin A | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Jung Mogg | - |
dc.contributor.affiliatedAuthor | Youn, Jeungyeun | - |
dc.identifier.doi | 10.1111/j.1365-3083.2006.001756.x | - |
dc.identifier.scopusid | 2-s2.0-33745536745 | - |
dc.identifier.wosid | 000238482900008 | - |
dc.identifier.bibliographicCitation | SCANDINAVIAN JOURNAL OF IMMUNOLOGY, v.63, no.6, pp.453 - 460 | - |
dc.relation.isPartOf | SCANDINAVIAN JOURNAL OF IMMUNOLOGY | - |
dc.citation.title | SCANDINAVIAN JOURNAL OF IMMUNOLOGY | - |
dc.citation.volume | 63 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 453 | - |
dc.citation.endPage | 460 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Immunology | - |
dc.relation.journalWebOfScienceCategory | Immunology | - |
dc.subject.keywordPlus | GENE-EXPRESSION | - |
dc.subject.keywordPlus | KINASE | - |
dc.subject.keywordPlus | PROTEIN-1 | - |
dc.subject.keywordPlus | PHOSPHORYLATION | - |
dc.subject.keywordPlus | INDUCTION | - |
dc.subject.keywordPlus | REGULATOR | - |
dc.subject.keywordPlus | SECRETION | - |
dc.subject.keywordPlus | INFECTION | - |
dc.subject.keywordPlus | APOPTOSIS | - |
dc.subject.keywordPlus | FAMILY | - |
dc.identifier.url | https://onlinelibrary.wiley.com/doi/10.1111/j.1365-3083.2006.001756.x | - |
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