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Profiling of differentially expressed genes in human stem cells by cDNA microarray

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dc.contributor.authorKim, Chul Geun-
dc.contributor.authorLee, Jong Joo-
dc.contributor.authorJung, Dae Young-
dc.contributor.authorJeon, Jinseon-
dc.contributor.authorHeo, Hyen Seok-
dc.contributor.authorKang, Ho Chul-
dc.contributor.authorShin, June Ho-
dc.contributor.authorCho, Yoon Shin-
dc.contributor.authorChat, Kyung Joon-
dc.contributor.authorKim, Chan Gil-
dc.contributor.authorDo, Byung-Rok-
dc.contributor.authorKim, Kyung Suk-
dc.contributor.authorKims, Hyun-Soo-
dc.date.accessioned2022-12-21T11:12:57Z-
dc.date.available2022-12-21T11:12:57Z-
dc.date.created2022-09-16-
dc.date.issued2006-06-
dc.identifier.issn1016-8478-
dc.identifier.urihttps://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/181400-
dc.description.abstractStem cells are unique cell populations with the ability to undergo both self-renewal and differentiation, although a wide variety of adult stem cells as well as embryonic stem cells have been identified and stem cell plasticity has recently been reported. To identify genes implicated in the control of the stem cell state as well as the characteristics of each stem cell line, we analyzed the expression profiles of genes in human embryonic, hematopoietic (CD34(+) and CD133(+)), and mesenchymal stem cells using cDNA microarrays, and identified genes that were differentially expressed in specific stem cell populations. In particular we were able to identify potential hESC signature-like genes that encode transcription factors (TFAP2C and MYCN), an RNA binding protein (IMP-3), and a functionally uncharacterized protein (MAGEA4). The overlapping sets of 22 up-regulated and 141 downregulated genes identified in this study of three human stem cell types may also provide insight into the developmental mechanisms common to all human stem cells. Furthermore, our comprehensive analyses of gene expression profiles in various adult stem cells may help to identify the genetic pathways involved in self-renewal as well as in multi-lineage specific differentiation.-
dc.language영어-
dc.language.isoen-
dc.publisherKOREAN SOC MOLECULAR & CELLULAR BIOLOGY-
dc.titleProfiling of differentially expressed genes in human stem cells by cDNA microarray-
dc.typeArticle-
dc.contributor.affiliatedAuthorKim, Chul Geun-
dc.contributor.affiliatedAuthorChat, Kyung Joon-
dc.identifier.scopusid2-s2.0-33745834792-
dc.identifier.wosid000238843800004-
dc.identifier.bibliographicCitationMOLECULES AND CELLS, v.21, no.3, pp.343 - 355-
dc.relation.isPartOfMOLECULES AND CELLS-
dc.citation.titleMOLECULES AND CELLS-
dc.citation.volume21-
dc.citation.number3-
dc.citation.startPage343-
dc.citation.endPage355-
dc.type.rimsART-
dc.type.docTypeArticle-
dc.identifier.kciidART001014437-
dc.description.journalClass1-
dc.description.isOpenAccessN-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.description.journalRegisteredClasskci-
dc.relation.journalResearchAreaBiochemistry & Molecular Biology-
dc.relation.journalResearchAreaCell Biology-
dc.relation.journalWebOfScienceCategoryBiochemistry & Molecular Biology-
dc.relation.journalWebOfScienceCategoryCell Biology-
dc.subject.keywordPlusMARROW STROMAL CELLS-
dc.subject.keywordPlusMOLECULAR SIGNATURE-
dc.subject.keywordPlusMOUSE-
dc.subject.keywordPlusLINES-
dc.subject.keywordPlusPLURIPOTENCY-
dc.subject.keywordPlusREGENERATION-
dc.subject.keywordPlusPROTEINS-
dc.subject.keywordPlusPATTERNS-
dc.subject.keywordPlusANTIGEN-
dc.subject.keywordPlusCLONING-
dc.subject.keywordAuthorcDNA microarray-
dc.subject.keywordAuthorexpression profiling-
dc.subject.keywordAuthorhuman CD34(+)-
dc.subject.keywordAuthorhematopoietic stem/progenitor cells-
dc.subject.keywordAuthorhuman CD133(+) hematopoietic-
dc.subject.keywordAuthorstem/progenitor cells-
dc.subject.keywordAuthorhuman embryonic stem cells-
dc.subject.keywordAuthorhuman mesenchymal stem cells-
dc.subject.keywordAuthorstem cell signature-
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서울 자연과학대학 > 서울 수학과 > 1. Journal Articles
서울 자연과학대학 > 서울 생명과학과 > 1. Journal Articles

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