Potent in vivo anti-breast cancer activity of IN-2001, a novel inhibitor of histone deacetylase, in MMTWc-Neu mice
DC Field | Value | Language |
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dc.contributor.author | Joung, Ki Eun | - |
dc.contributor.author | Min, Kyung-Nan | - |
dc.contributor.author | An, Jin Yong | - |
dc.contributor.author | Kim, Dae-Kee | - |
dc.contributor.author | Kong, Gu. | - |
dc.contributor.author | Sheen, Yhun Yhong | - |
dc.date.accessioned | 2022-12-21T11:24:43Z | - |
dc.date.available | 2022-12-21T11:24:43Z | - |
dc.date.created | 2022-09-16 | - |
dc.date.issued | 2006-05 | - |
dc.identifier.issn | 0008-5472 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/181519 | - |
dc.description.abstract | A novel synthetic inhibitor of historic deacetylase (HDAC), 3-(4-dimethylaminophenyl)-N-hydroxy-2-propenamide (IN-2001), was examined for its antitumor activity and for the underlying molecular mechanisms of any such activity. IN-2001 effectively inhibited cellular HDAC activity (IC50, 5.42 nmol/L) in MCF-7 human breast cancer cells. Based on the Western blot analysis, this HDAC inhibitory effect of IN-2001 was confirmed by an increase in histone 114 acetylation from the IN-2001-treated breast cancer cells. IN-2001 suppressed mammary tumor growth in MMTV/c-Neu transgenic mice and also showed higher apoptotic index and lower lymphatic invasion compared with controls. In human breast cancer cells (MCF-7, T47D, MDA-MB-231, and MDA-MB-468), IN-2001 induced cell cycle arrest at G(2)-M phase through up-regulation of p21(WAF1) and p27(KIP1) and eventually caused apoptosis. IN-2001-induced apoptosis was caspase dependent and seems mediated through an increase in Bax/Bcl-2 ratio. Taken together, our data indicate that this novel HDAC inhibitor is a promising therapeutic agent against human breast cancer. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | AMER ASSOC CANCER RESEARCH | - |
dc.title | Potent in vivo anti-breast cancer activity of IN-2001, a novel inhibitor of histone deacetylase, in MMTWc-Neu mice | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kong, Gu. | - |
dc.identifier.doi | 10.1158/0008-5472.CAN-05-3835 | - |
dc.identifier.scopusid | 2-s2.0-33744915538 | - |
dc.identifier.wosid | 000237679900052 | - |
dc.identifier.bibliographicCitation | CANCER RESEARCH, v.66, no.10, pp.5394 - 5402 | - |
dc.relation.isPartOf | CANCER RESEARCH | - |
dc.citation.title | CANCER RESEARCH | - |
dc.citation.volume | 66 | - |
dc.citation.number | 10 | - |
dc.citation.startPage | 5394 | - |
dc.citation.endPage | 5402 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Oncology | - |
dc.relation.journalWebOfScienceCategory | Oncology | - |
dc.subject.keywordPlus | SUBEROYLANILIDE HYDROXAMIC ACID | - |
dc.subject.keywordPlus | TRANSGENIC MICE | - |
dc.subject.keywordPlus | ANTITUMOR-ACTIVITY | - |
dc.subject.keywordPlus | GENE-EXPRESSION | - |
dc.subject.keywordPlus | TRICHOSTATIN-A | - |
dc.subject.keywordPlus | APOPTOSIS | - |
dc.subject.keywordPlus | INDUCTION | - |
dc.subject.keywordPlus | PATHWAY | - |
dc.subject.keywordPlus | BEARING | - |
dc.subject.keywordPlus | AGENT | - |
dc.identifier.url | https://aacrjournals.org/cancerres/article/66/10/5394/525638/Potent-In-vivo-Anti-Breast-Cancer-Activity-of-IN | - |
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