The effects of genetic polymorphisms of IL-1 and TNF-A on Helicobacter pylori-induced gastroduodenal diseases in Korea
DC Field | Value | Language |
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dc.contributor.author | Kim, Nayoung | - |
dc.contributor.author | Cho, Sung-Il | - |
dc.contributor.author | Yim, Jeong-Yoon | - |
dc.contributor.author | Kim, Jung Mogg | - |
dc.contributor.author | Lee, Dong Ho | - |
dc.contributor.author | Park, Ji Hyun | - |
dc.contributor.author | Kim, Joo Sung | - |
dc.contributor.author | Jung, Hyun Chae | - |
dc.contributor.author | Song, In Sung | - |
dc.date.accessioned | 2022-12-21T11:41:08Z | - |
dc.date.available | 2022-12-21T11:41:08Z | - |
dc.date.created | 2022-09-16 | - |
dc.date.issued | 2006-04 | - |
dc.identifier.issn | 1083-4389 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/181591 | - |
dc.description.abstract | Objective: To evaluate whether or not genetic polymorphism of IL-1B, IL-1RN, and TNF-A is an important factor in the different expression of gastroduodenal diseases after Helicobacter pylori infection. Methods: This study consisted of 1360 subjects: control, gastric cancer (GC, intestinal type, and diffuse type), benign gastric ulcer (BGU), duodenal ulcer, and first-degree gastric cancer relative (GCR). IL-1B-511 and TNF-A-308 biallelic polymorphism were genotyped by 5' nuclease polymerase chain reaction (PCR) assays, and PCR-restriction fragment length polymorphism (PCR-RFLP). IL-1RN penta-allelic variable number of tandem repeats was genotyped by PCR. Results: There was no difference in the genetic polymorphism of IL-1B-511, IL-1RN and TNF-A in the patients with gastric cancer regardless of H. pylori positivity compared with control. However, the frequencies of IL-1B-511 C/T (OR: 0.5, 95% CI: 0.3-0.7) and T carrier (OR: 0.6, 95% CI: 0.4-0.8) were lower in the H. pylori-positive BGU patients. The IL-1RN 2/2 was higher (OR: 5.5, 95% CI: 1.1-28.5) in the H. pylori-positive GCR. There was no significance in the polymorphism of TNF-A-308 regardless of H. pylori-induced gastroduodenal diseases. Conclusions: The IL-1B-511 T-carrier polymorphism has a negative effect on the development of H. pylori-positive BGU, and high frequency of IL-1RN 2/2 was found in the H. pylori-positive relatives of GC patients, which suggest that this genetic polymorphism could play some role in the H. pylori-induced gastroduodenal diseases in Korea. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | WILEY | - |
dc.title | The effects of genetic polymorphisms of IL-1 and TNF-A on Helicobacter pylori-induced gastroduodenal diseases in Korea | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Jung Mogg | - |
dc.identifier.doi | 10.1111/j.1523-5378.2006.00384.x | - |
dc.identifier.scopusid | 2-s2.0-33644843484 | - |
dc.identifier.wosid | 000235892300006 | - |
dc.identifier.bibliographicCitation | HELICOBACTER, v.11, no.2, pp.105 - 112 | - |
dc.relation.isPartOf | HELICOBACTER | - |
dc.citation.title | HELICOBACTER | - |
dc.citation.volume | 11 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 105 | - |
dc.citation.endPage | 112 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Gastroenterology & Hepatology | - |
dc.relation.journalResearchArea | Microbiology | - |
dc.relation.journalWebOfScienceCategory | Gastroenterology & Hepatology | - |
dc.relation.journalWebOfScienceCategory | Microbiology | - |
dc.subject.keywordPlus | NECROSIS-FACTOR-ALPHA | - |
dc.subject.keywordPlus | INHIBIT ACID-SECRETION | - |
dc.subject.keywordPlus | GASTRIC-CANCER | - |
dc.subject.keywordPlus | FAMILY-HISTORY | - |
dc.subject.keywordPlus | INTERLEUKIN-1 POLYMORPHISMS | - |
dc.subject.keywordPlus | ATROPHIC GASTRITIS | - |
dc.subject.keywordPlus | PARIETAL-CELLS | - |
dc.subject.keywordPlus | INCREASED RISK | - |
dc.subject.keywordPlus | INFECTION | - |
dc.subject.keywordPlus | CYTOKINE | - |
dc.subject.keywordAuthor | Helicobacter pylori | - |
dc.subject.keywordAuthor | Il-1B | - |
dc.subject.keywordAuthor | IL-1RN | - |
dc.subject.keywordAuthor | TNF-A | - |
dc.subject.keywordAuthor | genetic polymorphism | - |
dc.identifier.url | https://onlinelibrary.wiley.com/doi/10.1111/j.1523-5378.2006.00384.x | - |
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