Cysteinyl leukotriene receptor 1 promoter polymorphism is associated with aspirin-intolerant asthma in males
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Seung-Hyun | - |
dc.contributor.author | Oh, Jay Min | - |
dc.contributor.author | Kim, Yongseok | - |
dc.contributor.author | Palmer, Lyle John | - |
dc.contributor.author | Suh, Chang-Hee | - |
dc.contributor.author | Nahm, Dong-Ho | - |
dc.contributor.author | Park, Hae-Sim | - |
dc.date.accessioned | 2022-12-21T11:41:34Z | - |
dc.date.available | 2022-12-21T11:41:34Z | - |
dc.date.created | 2022-09-16 | - |
dc.date.issued | 2006-04 | - |
dc.identifier.issn | 0954-7894 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/181594 | - |
dc.description.abstract | Background Cysteinyl leukotrienes (CysLTs) play important roles in the pathogenesis of eosinophilic airway inflammation characterized by bronchoconstriction, mucus secretion and airway hyper-responsiveness via cysteinyl leukotriene receptor 1 (CysLTR1)-mediated mechanism. CysLTR1-selective antagonists have anti-bronchoconstrictive and anti-inflammatory effects in asthma, particularly aspirin-intolerant asthma (AIA). Methods To investigate the association of CysLTR1 with AIA development, we identified three single nucleotide polymorphisms (SNPs), -634C > T, -475A > C, -336A > G, in the 5' upstream region of CysLTR1 gene using a direct sequencing method in 105 AIA patients, 110 ASA-tolerant asthma (ATA) patients and 125 normal healthy controls (NC). Results Significant differences were observed in allele frequencies of the three SNPs within male subjects; Male AIA patients had higher frequencies of the minor alleles of these three SNPs than male control groups (P=0.03 for AIA vs. NC; P=0.02 for AIA vs. ATA). Moreover, three-SNP haplotype, ht2 [T-C-G], was associated with increased disease risk (odds ratio (OR)=2.71, P=0.03 for AIA vs. NC; OR=2.89, P=0.02 for AIA vs. ATA) in males. CysLTR1 haplotypes were also associated with altered gene expression; luciferase activity was significantly enhanced with the ht2 [T-C-G] construct in comparison with the ht1 [C-A-A] construct in human Jurkat cells (P=0.04). Conclusion These results suggest that genetic variants of CysLTR1 are associated with AIA in a Korean population, and may modulate CysLTR1 expression. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | WILEY-BLACKWELL | - |
dc.title | Cysteinyl leukotriene receptor 1 promoter polymorphism is associated with aspirin-intolerant asthma in males | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Yongseok | - |
dc.identifier.doi | 10.1111/j.1365-2222.2006.02457.x | - |
dc.identifier.scopusid | 2-s2.0-33645309625 | - |
dc.identifier.wosid | 000236241900004 | - |
dc.identifier.bibliographicCitation | CLINICAL AND EXPERIMENTAL ALLERGY, v.36, no.4, pp.433 - 439 | - |
dc.relation.isPartOf | CLINICAL AND EXPERIMENTAL ALLERGY | - |
dc.citation.title | CLINICAL AND EXPERIMENTAL ALLERGY | - |
dc.citation.volume | 36 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 433 | - |
dc.citation.endPage | 439 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Allergy | - |
dc.relation.journalResearchArea | Immunology | - |
dc.relation.journalWebOfScienceCategory | Allergy | - |
dc.relation.journalWebOfScienceCategory | Immunology | - |
dc.subject.keywordPlus | PERIPHERAL-BLOOD LEUKOCYTES | - |
dc.subject.keywordPlus | LYSINE-ASPIRIN | - |
dc.subject.keywordPlus | HUMAN LUNG | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | CELLS | - |
dc.subject.keywordPlus | ANTAGONIST | - |
dc.subject.keywordPlus | 5-LIPOXYGENASE | - |
dc.subject.keywordPlus | INFLAMMATION | - |
dc.subject.keywordPlus | MONTELUKAST | - |
dc.subject.keywordPlus | HAPLOTYPE | - |
dc.subject.keywordAuthor | aspirin-intolerant asthma | - |
dc.subject.keywordAuthor | cysteinyl leukotriene receptor 1 | - |
dc.subject.keywordAuthor | single nucleotide polymorphism | - |
dc.identifier.url | https://onlinelibrary.wiley.com/doi/10.1111/j.1365-2222.2006.02457.x | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
222, Wangsimni-ro, Seongdong-gu, Seoul, 04763, Korea+82-2-2220-1365
COPYRIGHT © 2021 HANYANG UNIVERSITY.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.