Angiotensin-converting enzyme gene insertion/deletion polymorphism in Korean patients with systemic sclerosis
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Joung, Chung-Il | - |
dc.contributor.author | Park, Yong-Wook | - |
dc.contributor.author | Kim, Sook-Kyoung | - |
dc.contributor.author | Uhm, Wan-Sik | - |
dc.contributor.author | Kim, Tae-Hwan | - |
dc.contributor.author | Yoo, Dae-Hyun | - |
dc.date.accessioned | 2022-12-21T11:45:27Z | - |
dc.date.available | 2022-12-21T11:45:27Z | - |
dc.date.created | 2022-08-26 | - |
dc.date.issued | 2006-04 | - |
dc.identifier.issn | 1011-8934 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/181628 | - |
dc.description.abstract | To determine whether angiotensin-converting enzyme (ACE) gene insertion/deletion (10) polymorphism is associated with the development and clinical features of systemic sclerosis (SSc) in Korean, we studied seventy two Korean patients with SSc fulfilling the ACR preliminary classification criteria. The controls were 114 healthy, disease free Koreans. ACE I/D genotypes were determined by PCR method using oligonucleotides. Sixty eight patients (94.4%) were women and age at diagnosis was 43.5 +/- 12.6 yr old (mean +/- SD). Thirty nine patients (54.2%) had a diffuse type of SSc. There were no statistical differences in the frequencies of all ACE I/D genotypes and D allele between patients and controls, and neither between diffuse and limited types of SSc. ACE I/D gene polymorphism was not associated with the development of SSc in Korea. The investigation for the pathogenesis of SSc requires more studies about the role of other candidate genes such as endothelin, TGF-beta, nitric oxide, or angiotensin II receptor in addition to the ACE genes. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | KOREAN ACAD MEDICAL SCIENCES | - |
dc.title | Angiotensin-converting enzyme gene insertion/deletion polymorphism in Korean patients with systemic sclerosis | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Tae-Hwan | - |
dc.contributor.affiliatedAuthor | Yoo, Dae-Hyun | - |
dc.identifier.doi | 10.3346/jkms.2006.21.2.329 | - |
dc.identifier.scopusid | 2-s2.0-33646814044 | - |
dc.identifier.wosid | 000237229900026 | - |
dc.identifier.bibliographicCitation | JOURNAL OF KOREAN MEDICAL SCIENCE, v.21, no.2, pp.329 - 332 | - |
dc.relation.isPartOf | JOURNAL OF KOREAN MEDICAL SCIENCE | - |
dc.citation.title | JOURNAL OF KOREAN MEDICAL SCIENCE | - |
dc.citation.volume | 21 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 329 | - |
dc.citation.endPage | 332 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART001115772 | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | General & Internal Medicine | - |
dc.relation.journalWebOfScienceCategory | Medicine, General & Internal | - |
dc.subject.keywordPlus | ENDOTHELIAL DYSFUNCTION | - |
dc.subject.keywordPlus | DELETION POLYMORPHISM | - |
dc.subject.keywordAuthor | scleroderma | - |
dc.subject.keywordAuthor | systemic | - |
dc.subject.keywordAuthor | angiotensin-convening enzyme | - |
dc.subject.keywordAuthor | peptidyl-dipeptidase A | - |
dc.subject.keywordAuthor | polymorphism | - |
dc.subject.keywordAuthor | genetic | - |
dc.subject.keywordAuthor | Korea | - |
dc.identifier.url | https://jkms.org/DOIx.php?id=10.3346/jkms.2006.21.2.329 | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
222, Wangsimni-ro, Seongdong-gu, Seoul, 04763, Korea+82-2-2220-1365
COPYRIGHT © 2021 HANYANG UNIVERSITY.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.