류마티스 관절염 환자에서 HLA-DRB1의 유전적 변이와Etanercept 치료 반응과의 연관성: 예비 연구
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 윤혜련 | - |
dc.contributor.author | 강창수 | - |
dc.contributor.author | 이경화 | - |
dc.contributor.author | 이혜순 | - |
dc.contributor.author | 김태환 | - |
dc.contributor.author | 배상철 | - |
dc.date.accessioned | 2022-12-21T11:48:26Z | - |
dc.date.available | 2022-12-21T11:48:26Z | - |
dc.date.created | 2022-09-19 | - |
dc.date.issued | 2006-03 | - |
dc.identifier.issn | 2093-940X | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/181662 | - |
dc.description.abstract | Objective: To investigate the roles of genetic variation in the HLA-DRB1 as predictors of response to etanercept treatment in rheumatoid arthritis (RA) patients. Methods: Clinical responses of 66 patients treated with etanercept were determined according to the ACR criteria (ACR20 and 70). HLA-DRB1 typing and further subtyping of all alleles were performed by polymerase chain reaction, sequence-specific oligonucleotide probe hybridization, and direct DNA sequencing analysis. We tested whether genetic variation in the HLA-DRB1 influenced on the responses to 12 weeks of etanercept therapy. Univariate and multivariate analyses were performed to compare allele and genotype distribution between responders and nonresponders. Results: When allelic association with etanercept response was analyzed with ACR20 and ACR 70 criteria for shared epitope alleles (HLA-DRB1 *0101, *0401, *0404, *0405, *0410, *1001,and *1406 alleles) and protective alleles (HLA-DRB1*0701, *0802, *1301, *1302, *1403, and *1405 alleles), there was no association with etanercept efficacy. When ACR20 nonresponders were compared with ACR70 responders, there was no significant association. Next, we tested genotypic association for shared epitope carriage status. The presence of HLA-DRB1 alleles encoding the shared epitope (1 and 2 copies) was marginally associated with nonresponse effect for ACR 70 response (OR=0.27, 95% CI=0.08~0.93, P=0.045). Conclusion: There was no influence of genetic variation in the HLA-DRB1 on the response to treatment of RA with etanercept. | - |
dc.language | 한국어 | - |
dc.language.iso | ko | - |
dc.publisher | 대한류마티스학회 | - |
dc.title | 류마티스 관절염 환자에서 HLA-DRB1의 유전적 변이와Etanercept 치료 반응과의 연관성: 예비 연구 | - |
dc.title.alternative | Genetic Variation in the HLA-DRB1 and the Response to Treatment of Rheumatoid Arthritis with Etanercept: Preliminary Study | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | 이혜순 | - |
dc.contributor.affiliatedAuthor | 김태환 | - |
dc.contributor.affiliatedAuthor | 배상철 | - |
dc.identifier.bibliographicCitation | 대한류마티스학회지, v.13, no.1, pp.10 - 17 | - |
dc.relation.isPartOf | 대한류마티스학회지 | - |
dc.citation.title | 대한류마티스학회지 | - |
dc.citation.volume | 13 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 10 | - |
dc.citation.endPage | 17 | - |
dc.type.rims | ART | - |
dc.identifier.kciid | ART001154322 | - |
dc.description.journalClass | 2 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | kci | - |
dc.subject.keywordAuthor | Rheumatoid arthritis | - |
dc.subject.keywordAuthor | Etanercept | - |
dc.subject.keywordAuthor | HLA-DRB1 | - |
dc.subject.keywordAuthor | Rheumatoid arthritis | - |
dc.subject.keywordAuthor | Etanercept | - |
dc.subject.keywordAuthor | HLA-DRB1 | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
222, Wangsimni-ro, Seongdong-gu, Seoul, 04763, Korea+82-2-2220-1365
COPYRIGHT © 2021 HANYANG UNIVERSITY.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.