Erythropoietin, modified to not stimulate red blood cell production, retains its cardioprotective properties
DC Field | Value | Language |
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dc.contributor.author | Moon, Chanil | - |
dc.contributor.author | Krawczyk, Melissa | - |
dc.contributor.author | Paik, Doojin | - |
dc.contributor.author | Coleman, Thomas | - |
dc.contributor.author | Brines, Michael | - |
dc.contributor.author | Juhaszova, Magdalena | - |
dc.contributor.author | Sollott, Steven J. | - |
dc.contributor.author | Lakatta, Edward G | - |
dc.contributor.author | Talan, Mark I | - |
dc.date.accessioned | 2022-12-21T11:50:48Z | - |
dc.date.available | 2022-12-21T11:50:48Z | - |
dc.date.created | 2022-09-16 | - |
dc.date.issued | 2006-03 | - |
dc.identifier.issn | 0022-3565 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/181684 | - |
dc.description.abstract | Erythropoietin ( EPO), a hematopoietic cytokine, possesses strong antiapoptotic, tissue-protective properties. For clinical applications, it is desirable to separate the hematopoietic and tissue-protective properties. Recently introduced carbamylated erythropoietin ( CEPO) does not stimulate the erythropoiesis but retains the antiapoptotic and neuroprotective effects. We tested the ability of CEPO to protect cardiac tissue from toxin-induced and oxidative stress in vitro and ischemic damage in vivo and compared these effects with the effects of EPO. CEPO reduced by 50% the extent of staurosporine-induced apoptosis in isolated rats' cardiomyocytes and increased by 25% the reactive oxygen species threshold for induction of the mitochondrial permeability transition. In an experimental model of myocardial infarction induced by permanent ligation of a coronary artery in rats, similarly to EPO, a single bolus injection of 30 mu g/kg b.wt. of CEPO immediately after coronary ligation reduced apoptosis in the myocardial area at risk, examined 24 h later, by 50%. Left ventricular remodeling ( ventricular dilation) and functional decline ( fall in ejection fraction) assessed by repeated echocardiography were significantly and similarly attenuated in CEPO- and EPO-treated rats. Four weeks after coronary ligation, the myocardial infarction (MI) size in CEPO- and EPO- treated rats was half of that in untreated coronary-ligated animals. Unlike EPO, CEPO had no effect on hematocrit. The antiapoptotic cardioprotective effects of CEPO, shown by its ability to limit both post-MI left ventricular remodeling and the extent of the myocardial scar in the model of permanent coronary artery ligation in rats, demonstrate comparable potency to that of native ( nonmodified) EPO. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | AMER SOC PHARMACOLOGY EXPERIMENTAL THERAPEUTICS | - |
dc.title | Erythropoietin, modified to not stimulate red blood cell production, retains its cardioprotective properties | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Paik, Doojin | - |
dc.identifier.doi | 10.1124/jpet.105.094854 | - |
dc.identifier.scopusid | 2-s2.0-33644775862 | - |
dc.identifier.wosid | 000235476000004 | - |
dc.identifier.bibliographicCitation | JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, v.316, no.3, pp.999 - 1005 | - |
dc.relation.isPartOf | JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS | - |
dc.citation.title | JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS | - |
dc.citation.volume | 316 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 999 | - |
dc.citation.endPage | 1005 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.subject.keywordPlus | MITOCHONDRIAL PERMEABILITY TRANSITION | - |
dc.subject.keywordPlus | ISCHEMIA-REPERFUSION INJURY | - |
dc.subject.keywordPlus | MYOCARDIAL-INFARCTION | - |
dc.subject.keywordPlus | MYOCYTE APOPTOSIS | - |
dc.subject.keywordPlus | CARDIAC MYOCYTES | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | PROTECTION | - |
dc.subject.keywordPlus | ARTERY | - |
dc.subject.keywordPlus | HEART | - |
dc.subject.keywordPlus | RATS | - |
dc.identifier.url | https://jpet.aspetjournals.org/content/316/3/999 | - |
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