Catalase and PPAR gamma 2 genotype and risk of rheumatoid arthritis in Koreans

Abstract

Catalase ( CAT) and peroxisome proliferator activated receptor-gamma 2 ( PPAR gamma 2) are important regulators of oxidative stress and inflammation, and may contribute to the development of rheumatoid arthritis ( RA). We investigated the association between CAT and PPAR gamma 2 genotypes and risk and severity of RA using 474 cases and 400 controls. Genotyping for the -262C -> T polymorphism of CAT and the Pro12Ala polymorphism of PPAR gamma 2 was performed by PCR-RFLP analysis. Severity of RA was assessed by the anatomical stage according to Steinbrocker, and a Korean language version of a Health Assessment Questionnaire ( KHAQ). No association was observed between CAT and PPAR gamma 2 genotypes and risk of RA. Our results suggest that genetic polymorphisms of CAT and PPAR gamma 2 do not play a significant role in the susceptibility to RA among Koreans.