Metastasis-associated protein 1 enhances stability of hypoxia-inducible factor-1 alpha protein by recruiting histone deacetylase 1
DC Field | Value | Language |
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dc.contributor.author | Yoo, Young-Gun | - |
dc.contributor.author | Kong, Gu | - |
dc.contributor.author | Lee, Mi-Ock | - |
dc.date.accessioned | 2022-12-21T11:56:33Z | - |
dc.date.available | 2022-12-21T11:56:33Z | - |
dc.date.created | 2022-08-26 | - |
dc.date.issued | 2006-03 | - |
dc.identifier.issn | 0261-4189 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/181734 | - |
dc.description.abstract | The expression of metastasis-associated protein 1 (MTA1) correlates well with tumor metastases; however, the associated molecular mechanism is not fully understood. Here, we explored the possibility of cross-talk between MTA1 and hypoxia-inducible factor-1 alpha (HIF-1 alpha), a key regulator of angiogenic factors. We observed that the expression of MTA1 was strongly induced under hypoxia in breast cancer cell lines such as MCF-7 and MDA-MB-231. When MTA1 was overexpressed, the transcriptional activity and stability of HIF-1 alpha protein were enhanced. MTA1 and HIF-1 alpha are physically associated in vivo and they were localized completely in the nucleus when coexpressed. MTA1 induced the deacetylation of HIF-1 alpha by increasing the expression of histone deacetylase 1 (HDAC1). MTA1 counteracted to the action of acetyltransferase, ARD1, and it did not stabilize the HIF-1 alpha mutant that lacks the acetylation site, K532R. These results indicate that acetylation is the major target of MTA1/HDAC1 function. Collectively, our data provide evidence of a positive cross-talk between HIF-1 alpha and MTA1, which is mediated by HDAC1 recruitment, and indicate a close connection between MTA1-associated metastasis and HIF-1-induced tumor angiogenesis. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | WILEY | - |
dc.title | Metastasis-associated protein 1 enhances stability of hypoxia-inducible factor-1 alpha protein by recruiting histone deacetylase 1 | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kong, Gu | - |
dc.identifier.doi | 10.1038/sj.emboj.7601025 | - |
dc.identifier.scopusid | 2-s2.0-33645322383 | - |
dc.identifier.wosid | 000236737700006 | - |
dc.identifier.bibliographicCitation | EMBO JOURNAL, v.25, no.6, pp.1231 - 1241 | - |
dc.relation.isPartOf | EMBO JOURNAL | - |
dc.citation.title | EMBO JOURNAL | - |
dc.citation.volume | 25 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 1231 | - |
dc.citation.endPage | 1241 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Cell Biology | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Cell Biology | - |
dc.subject.keywordPlus | HYPOXIA-INDUCIBLE FACTOR-1-ALPHA | - |
dc.subject.keywordPlus | VIRUS-X PROTEIN | - |
dc.subject.keywordPlus | HUMAN MTA1 GENE | - |
dc.subject.keywordPlus | BREAST-CANCER | - |
dc.subject.keywordPlus | ESTROGEN-RECEPTOR | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | ALPHA | - |
dc.subject.keywordPlus | OVEREXPRESSION | - |
dc.subject.keywordPlus | HIF-1-ALPHA | - |
dc.subject.keywordPlus | FAMILY | - |
dc.subject.keywordAuthor | HDAC1 | - |
dc.subject.keywordAuthor | HIF-1 alpha | - |
dc.subject.keywordAuthor | hypoxia | - |
dc.subject.keywordAuthor | metastasis | - |
dc.subject.keywordAuthor | MTA1 | - |
dc.identifier.url | https://www.embopress.org/doi/full/10.1038/sj.emboj.7601025 | - |
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