Prevention of spontaneous arthritis by inhibiting homeostatic expansion of autoreactive CD4+ T cells in the K/BxN mouse model
DC Field | Value | Language |
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dc.contributor.author | Jang, Eunkyeorig | - |
dc.contributor.author | Kim, Hong Ro | - |
dc.contributor.author | Cho, Sin Hye | - |
dc.contributor.author | Paik, Doo Jin | - |
dc.contributor.author | Kim, Jung Mogg | - |
dc.contributor.author | Lee, Sang-Koo | - |
dc.contributor.author | Youn, Jee hee | - |
dc.date.accessioned | 2022-12-21T12:00:53Z | - |
dc.date.available | 2022-12-21T12:00:53Z | - |
dc.date.created | 2022-08-29 | - |
dc.date.issued | 2006-02 | - |
dc.identifier.issn | 0004-3591 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/181770 | - |
dc.description.abstract | Objective. K/BxN-transgenic mice are a model of autoimmune arthritis, similar to rheumatoid arthritis. This study was undertaken to determine whether inhibition of lymphopenia-provoked homeostatic expansion can prevent spontaneous development of disease in the K/BxN model. Methods. To inhibit homeostatic expansion of autoreactive T cells, K/BxN mice with disease in the preclinical stage were adoptively transferred with CD4+ T cells purified from nontransgenic BxN or Thy1.1+ BxN mice. To observe the profile of proliferation of CD4+ T cells derived from the hosts, carboxyfluorescein diacetate succinimidyl ester-labeled autologous CD4+ T cells were cotransferred to K/BxN mice together with BxN CD4+ T cells. Disease onset and progression were scored, and the dynamics and phenotypes of recipient CD4+ T cells were determined by flow cytometry, before and after cell infusion. Results. During the preclinical phase of disease, K/BxN mice exhibited CD4+ T lymphopenia, which was followed by a compensatory expansion of these cells during the early clinical phase. The majority of CD4+ T cells acquired a memory phenotype (CD44(high) CD62L(low), CD25-), which is a hallmark of homeostatically expanding cells. Importantly, K/BxN mice subjected to syngeneic T cell transfer did not develop symptoms of arthritis and also possessed fewer transgenic T cell receptor-encoded V(beta)6+,CD4+ T cells. This effect was associated with decreased proliferation of recipient-derived CD4+ T cells but not with the function of CD25+ T regulatory cells present in donor cells. Conclusion. These results provide the first evidence that lymphopenia-associated homeostatic proliferation of autoreactive CD4+ T cells potentiates autoimmune arthritis, and that inhibition of this process protects mice from the development of this pathologic condition. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | WILEY | - |
dc.title | Prevention of spontaneous arthritis by inhibiting homeostatic expansion of autoreactive CD4+ T cells in the K/BxN mouse model | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Paik, Doo Jin | - |
dc.contributor.affiliatedAuthor | Kim, Jung Mogg | - |
dc.contributor.affiliatedAuthor | Youn, Jee hee | - |
dc.identifier.doi | 10.1002/art.21567 | - |
dc.identifier.scopusid | 2-s2.0-32444447027 | - |
dc.identifier.wosid | 000235353200013 | - |
dc.identifier.bibliographicCitation | ARTHRITIS AND RHEUMATISM, v.54, no.2, pp.492 - 498 | - |
dc.relation.isPartOf | ARTHRITIS AND RHEUMATISM | - |
dc.citation.title | ARTHRITIS AND RHEUMATISM | - |
dc.citation.volume | 54 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 492 | - |
dc.citation.endPage | 498 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Rheumatology | - |
dc.relation.journalWebOfScienceCategory | Rheumatology | - |
dc.subject.keywordPlus | carboxyfluorescein diacetate succinimidyl ester | - |
dc.subject.keywordPlus | CD4 antigen | - |
dc.subject.keywordPlus | Hermes antigen | - |
dc.subject.keywordPlus | interleukin 2 receptor alpha | - |
dc.subject.keywordPlus | PADGEM protein | - |
dc.identifier.url | https://onlinelibrary.wiley.com/doi/10.1002/art.21567 | - |
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