Beta-glucan이 Azoxymethane을 투여한 F344 Rats의 대장 암화 과정에 미치는 영향

Abstract

This study was designed to investigate the preventive effect of the β-glucan on colon cancer using forty 21-day old male Fisher 344 rats. The colon cancer was induced by injections with colon carcinogen azoxymethane (15 mg AOM/kg body weight/time) at 4 and 5 weeks of age. All the rats were divided into control and experimental groups (n=10/group, β-glucan 1, 10, 100 ppm). The rats were fed normal diets ad libitum, and β-glucan was supplemented by intragastric intubation for 5 weeks. On week 5, all the rats were sacrificed. Body weight, food consumption weight, cecum pH, aberrant crypt (AC), aberrant crypt foci (ACF) were measured. Body weight and food consumption were not differ among control and experimental groups. The cecum pH and the number of AC in experimental group (β-glucan 10, 100 ppm oral feeding groups) were significantly lower than those of the control groups (p＜0.05). The number of ACF in experimental group (β-glucan 100 ppm oral feeding groups) was significantly lower than that of in control groups (p＜0.05). These results show that β-glucan may inhibit colon carcinogenesis through diverse mechanism. Therefore, further studies are needed to identify the mechanisms by which β-glucan inhibit colon cancer.