On-chip sample preconcentration for integrated microfluidic analysis

Abstract

The sample preconcentration methods which incorporates sample cleanup, sample concentration, mixing and reaction before analysis, in microchips are explained. Microfluidic chips have enabled miniaturization of many biochemical techniques that has resulted into faster and cheaper analysis using small amounts of samples and reagents. Sample preconcentration is an important step in the development of multifunctional integrated microfluidic devices. It enable detection of trace or low abundant species. It improves detection sensitivity and also the reliability of analysis by increasing signal-to-noise ratio.