Adipocytolytic Polymer Nanoparticles for Localized Fat Reduction
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Han, Young Kyoung | - |
dc.contributor.author | Jeong, Eun Ju | - |
dc.contributor.author | Seo, Yerang | - |
dc.contributor.author | Lee, In Young | - |
dc.contributor.author | Choi, Suim | - |
dc.contributor.author | Lee, Hyewon | - |
dc.contributor.author | Kim, Choonggu | - |
dc.contributor.author | Rhim, Taiyoun | - |
dc.contributor.author | Lee, Kuen Yong | - |
dc.date.accessioned | 2023-01-25T10:07:47Z | - |
dc.date.available | 2023-01-25T10:07:47Z | - |
dc.date.created | 2023-01-05 | - |
dc.date.issued | 2023-01 | - |
dc.identifier.issn | 1936-0851 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/182222 | - |
dc.description.abstract | The demand for body fat reduction is increasing. However, conventional lipolytic approaches fail to control adipose tissue reduction and cause severe side effects in adjacent nonadipose tissues. A strategy to specifically reduce subcutaneous fat using adipocytolytic polymer nanoparticles in a minimally invasive manner is reported here. The polymer nanoparticles are designed to generate carbon dioxide gas when selectively absorbed by adipocytes. The carbon dioxide gas generated within late endosomes/lysosomes induces adipocytolysis, thereby reducing the number of cells. Localized injection of the adipocytolytic nanoparticles substantially reduces subcutaneous fat in a high-fat diet-induced obese mouse model, without significant changes in hematological or serum biochemical parameters. The adipocytolytic efficacy of the nanoparticles is also evaluated in a porcine model. This strategy addresses the need to develop safe and effective adipocytolytic agents using functional polymer nanoparticles. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | AMER CHEMICAL SOC | - |
dc.title | Adipocytolytic Polymer Nanoparticles for Localized Fat Reduction | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Rhim, Taiyoun | - |
dc.contributor.affiliatedAuthor | Lee, Kuen Yong | - |
dc.identifier.doi | 10.1021/acsnano.2c04108 | - |
dc.identifier.scopusid | 2-s2.0-85144445420 | - |
dc.identifier.wosid | 000901654400001 | - |
dc.identifier.bibliographicCitation | ACS NANO, v.17, no.1, pp.70 - 83 | - |
dc.relation.isPartOf | ACS NANO | - |
dc.citation.title | ACS NANO | - |
dc.citation.volume | 17 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 70 | - |
dc.citation.endPage | 83 | - |
dc.type.rims | ART | - |
dc.type.docType | Article; Early Access | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalResearchArea | Materials Science | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Multidisciplinary | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Physical | - |
dc.relation.journalWebOfScienceCategory | Nanoscience & Nanotechnology | - |
dc.relation.journalWebOfScienceCategory | Materials Science, Multidisciplinary | - |
dc.subject.keywordPlus | SUBCUTANEOUS FAT | - |
dc.subject.keywordPlus | DELIVERY | - |
dc.subject.keywordPlus | OBESITY | - |
dc.subject.keywordPlus | DRUGS | - |
dc.subject.keywordAuthor | adipocytolysis | - |
dc.subject.keywordAuthor | local injection | - |
dc.subject.keywordAuthor | fat reduction | - |
dc.subject.keywordAuthor | polymer nanoparticle | - |
dc.subject.keywordAuthor | carbon dioxide gas | - |
dc.identifier.url | https://pubs.acs.org/doi/10.1021/acsnano.2c04108 | - |
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