MUC5B promoter variant rs35705950, rare but significant susceptibility locus in rheumatoid arthritis-interstitial lung disease with usual interstitial pneumonia in Asian populations
DC Field | Value | Language |
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dc.contributor.author | Joo, Young Bin | - |
dc.contributor.author | Ahn, Soo Min | - |
dc.contributor.author | Bang, So-Young | - |
dc.contributor.author | Park, Youngho | - |
dc.contributor.author | Hong, Su Jin | - |
dc.contributor.author | Lee, Youkyung | - |
dc.contributor.author | Cho, Soo-Kyung | - |
dc.contributor.author | Choi, Chan-Bum | - |
dc.contributor.author | Sung, Yoon-Kyoung | - |
dc.contributor.author | Kim, Tae-Hwan | - |
dc.contributor.author | Jun, Jae-Bum | - |
dc.contributor.author | Yoo, Dae Hyun | - |
dc.contributor.author | Bae, Sang-Cheol | - |
dc.contributor.author | Lee, Hye-Soon | - |
dc.date.accessioned | 2023-02-21T05:31:36Z | - |
dc.date.available | 2023-02-21T05:31:36Z | - |
dc.date.created | 2023-02-08 | - |
dc.date.issued | 2022-12 | - |
dc.identifier.issn | 2056-5933 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/182348 | - |
dc.description.abstract | Background MUC5B variant rs35705950 is the common and most significant risk variant for rheumatoid arthritis-interstitial lung disease (RA-ILD) in Western populations. However, little is known about its significant association with RA-ILD in Asian populations. We here investigate the association of rs35705950 with Korean patients with RA-ILD. Methods In this cross-sectional study, we genotyped rs35705950 in 2444 patients with RA. Among them, 683 patients with RA who have chest CT were divided into RA-ILD and RA-noILD. RA-ILD was classified as usual interstitial pneumonia (UIP) and other than UIP. The associations of rs35705950 with RA-ILD and its subtype were analysed using multivariable regression adjusted for age at RA diagnosis. Meta-analysis of a previously reported Japanese dataset and Korean dataset obtained for this study was conducted. Results The minor allele (T) frequency of rs35705950 was 0.37%, 1.43% and 2.38% in 2444 patients with RA, 105 patients with RA-ILD and 63 patients with UIP, respectively. Genotypic association of rs35705950 with RA-ILD was insignificant (OR 2.49, 95% CI 0.64 to 9.69, p=0.187), but showed significant association with UIP (OR 4.90, 95% CI 1.23 to 19.59, p=0.024) compared with RA-noILD. In meta-analysis (123 UIP and 878 RA-noILD) combining our data with previously reported Japanese data, this variant was found to be significantly associated with UIP (OR 3.51, 95% CI 1.19 to 10.37, p=0.023). Conclusion MUC5B variant rs35705950 is a rare but significant risk factor for Asian patients with RA-ILD with UIP, suggesting a sharing of the genetic background between Asian and Western populations. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | BMJ PUBLISHING GROUP | - |
dc.title | MUC5B promoter variant rs35705950, rare but significant susceptibility locus in rheumatoid arthritis-interstitial lung disease with usual interstitial pneumonia in Asian populations | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Bang, So-Young | - |
dc.contributor.affiliatedAuthor | Hong, Su Jin | - |
dc.contributor.affiliatedAuthor | Lee, Youkyung | - |
dc.contributor.affiliatedAuthor | Cho, Soo-Kyung | - |
dc.contributor.affiliatedAuthor | Choi, Chan-Bum | - |
dc.contributor.affiliatedAuthor | Sung, Yoon-Kyoung | - |
dc.contributor.affiliatedAuthor | Kim, Tae-Hwan | - |
dc.contributor.affiliatedAuthor | Jun, Jae-Bum | - |
dc.contributor.affiliatedAuthor | Yoo, Dae Hyun | - |
dc.contributor.affiliatedAuthor | Bae, Sang-Cheol | - |
dc.contributor.affiliatedAuthor | Lee, Hye-Soon | - |
dc.identifier.doi | 10.1136/rmdopen-2022-002790 | - |
dc.identifier.scopusid | 2-s2.0-85145152815 | - |
dc.identifier.wosid | 000906029900002 | - |
dc.identifier.bibliographicCitation | RMD OPEN, v.8, no.2, pp.1 - 7 | - |
dc.relation.isPartOf | RMD OPEN | - |
dc.citation.title | RMD OPEN | - |
dc.citation.volume | 8 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 1 | - |
dc.citation.endPage | 7 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Rheumatology | - |
dc.relation.journalWebOfScienceCategory | Rheumatology | - |
dc.subject.keywordPlus | IDIOPATHIC PULMONARY-FIBROSIS | - |
dc.subject.keywordPlus | POLYMORPHISM | - |
dc.subject.keywordPlus | CLASSIFICATION | - |
dc.subject.keywordPlus | ASSOCIATION | - |
dc.subject.keywordPlus | MORTALITY | - |
dc.subject.keywordPlus | CRITERIA | - |
dc.subject.keywordPlus | RISK | - |
dc.subject.keywordAuthor | arthritis | - |
dc.subject.keywordAuthor | rheumatoid | - |
dc.subject.keywordAuthor | polymorphism | - |
dc.subject.keywordAuthor | genetic | - |
dc.identifier.url | https://rmdopen.bmj.com/content/8/2/e002790 | - |
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