Deletion of PD-1 destabilizes the lineage identity and metabolic fitness of tumor-infiltrating regulatory T cells
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Myeong Joon | - |
dc.contributor.author | Kim, Kyungsoo | - |
dc.contributor.author | Park, Hyo Jin | - |
dc.contributor.author | Kim, Gil-Ran | - |
dc.contributor.author | Hong, Kyeong Hee | - |
dc.contributor.author | Oh, Ji Hoon | - |
dc.contributor.author | Son, Jimin | - |
dc.contributor.author | Park, Dong Jin | - |
dc.contributor.author | Kim, Dahae | - |
dc.contributor.author | Choi, Je-Min | - |
dc.contributor.author | Lee, Insuk | - |
dc.contributor.author | Ha, Sang-Jun | - |
dc.date.accessioned | 2023-05-03T10:00:40Z | - |
dc.date.available | 2023-05-03T10:00:40Z | - |
dc.date.created | 2023-03-08 | - |
dc.date.issued | 2023-01 | - |
dc.identifier.issn | 1529-2908 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/185000 | - |
dc.description.abstract | Regulatory T (T-reg) cells have an immunosuppressive function and highly express the immune checkpoint receptor PD-1 in the tumor microenvironment; however, the function of PD-1 in tumor-infiltrating (TI) T-reg cells remains controversial. Here, we showed that conditional deletion of PD-1 in T-reg cells delayed tumor progression. In Pdcd1(fl/fl)Foxp3(eGFP-Cre-ERT2(+/-)) mice, in which both PD-1-expressing and PD-1-deficient T-reg cells coexisted in the same tissue environment, conditional deletion of PD-1 in T-reg cells resulted in impairment of the proliferative and suppressive capacity of TI T-reg cells. PD-1 antibody therapy reduced the TI T-reg cell numbers, but did not directly restore the cytokine production of TI CD8(+) T cells in TC-1 lung cancer. Single-cell analysis indicated that PD-1 signaling promoted lipid metabolism, proliferation and suppressive pathways in TI T-reg cells. These results suggest that PD-1 ablation or inhibition can enhance antitumor immunity by weakening T-reg cell lineage stability and metabolic fitness in the tumor microenvironment. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | NATURE PORTFOLIO | - |
dc.title | Deletion of PD-1 destabilizes the lineage identity and metabolic fitness of tumor-infiltrating regulatory T cells | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Choi, Je-Min | - |
dc.identifier.doi | 10.1038/s41590-022-01373-1 | - |
dc.identifier.scopusid | 2-s2.0-85145034017 | - |
dc.identifier.wosid | 000905563600001 | - |
dc.identifier.bibliographicCitation | NATURE IMMUNOLOGY, v.24, no.1, pp.148 - 161 | - |
dc.relation.isPartOf | NATURE IMMUNOLOGY | - |
dc.citation.title | NATURE IMMUNOLOGY | - |
dc.citation.volume | 24 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 148 | - |
dc.citation.endPage | 161 | - |
dc.type.rims | ART | - |
dc.type.docType | Article; Early Access | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Immunology | - |
dc.relation.journalWebOfScienceCategory | Immunology | - |
dc.subject.keywordPlus | FOXP3 | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | DIFFERENTIATION | - |
dc.subject.keywordPlus | SUPPRESSION | - |
dc.subject.keywordPlus | GENERATION | - |
dc.subject.keywordPlus | VIRUS | - |
dc.subject.keywordPlus | MICE | - |
dc.identifier.url | https://www.nature.com/articles/s41590-022-01373-1 | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
222, Wangsimni-ro, Seongdong-gu, Seoul, 04763, Korea+82-2-2220-1365
COPYRIGHT © 2021 HANYANG UNIVERSITY.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.