Dissolvable Self-Locking Microneedle Patches Integrated with Immunomodulators for Cancer Immunotherapy
DC Field | Value | Language |
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dc.contributor.author | Joo, Seung-Hwan | - |
dc.contributor.author | Kim, Jaehyun | - |
dc.contributor.author | Hong, Juhyeong | - |
dc.contributor.author | Lahiji, Shayan Fakhraei | - |
dc.contributor.author | Kim, Yong Hee | - |
dc.date.accessioned | 2023-05-03T10:05:42Z | - |
dc.date.available | 2023-05-03T10:05:42Z | - |
dc.date.created | 2023-02-08 | - |
dc.date.issued | 2023-03 | - |
dc.identifier.issn | 0935-9648 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/185028 | - |
dc.description.abstract | Advancements in micro-resolution 3D printers have significantly facilitated the development of highly complex mass-producible drug delivery platforms. Conventionally, due to the limitations of micro-milling machineries, dissolvable microneedles (MNs) are mainly fabricated in cone-shaped geometry with limited drug delivery accuracy. Herein, to overcome the limitations of conventional MNs, a novel projection micro-stereolithography 3D printer-based self-locking MN for precise skin insertion, adhesion, and transcutaneous microdose drug delivery is presented. The geometry of self-locking MN consists of a sharp skin-penetrating tip, a wide skin interlocking body, and a narrow base with mechanical supports fabricated over a flexible hydrocolloid patch to improve the accuracy of skin penetration into irregular surfaces. Melanoma, a type of skin cancer, is selected as the model for the investigation of self-locking MNs due to its irregular and uneven surface. In vivo immunotherapy efficacy is evaluated by integrating SD-208, a novel transforming growth factor-β (TGF-β) inhibitor that suppresses the proliferation and metastasis of tumors, and anti-PD-L1 (aPD-L1 Ab), an immune checkpoint inhibitor that induces T cell-mediated tumor cell death, into self-locking MNs and comparing them with intratumoral injection. Evaluation of (aPD-L1 Ab)/SD-208 delivery effectiveness in B16F10 melanoma-bearing mice model confirms significantly improved dose efficacy of self-locking MNs compared with intratumoral injection. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | WILEY-V C H VERLAG GMBH | - |
dc.title | Dissolvable Self-Locking Microneedle Patches Integrated with Immunomodulators for Cancer Immunotherapy | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Yong Hee | - |
dc.identifier.doi | 10.1002/adma.202209966 | - |
dc.identifier.scopusid | 2-s2.0-85146445189 | - |
dc.identifier.wosid | 000914650800001 | - |
dc.identifier.bibliographicCitation | ADVANCED MATERIALS, v.35, no.10, pp.1 - 13 | - |
dc.relation.isPartOf | ADVANCED MATERIALS | - |
dc.citation.title | ADVANCED MATERIALS | - |
dc.citation.volume | 35 | - |
dc.citation.number | 10 | - |
dc.citation.startPage | 1 | - |
dc.citation.endPage | 13 | - |
dc.type.rims | ART | - |
dc.type.docType | Article in Press | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalResearchArea | Materials Science | - |
dc.relation.journalResearchArea | Physics | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Multidisciplinary | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Physical | - |
dc.relation.journalWebOfScienceCategory | Nanoscience & Nanotechnology | - |
dc.relation.journalWebOfScienceCategory | Materials Science, Multidisciplinary | - |
dc.relation.journalWebOfScienceCategory | Physics, Applied | - |
dc.relation.journalWebOfScienceCategory | Physics, Condensed Matter | - |
dc.subject.keywordPlus | MELANOMA | - |
dc.subject.keywordPlus | DRUG | - |
dc.subject.keywordPlus | SKIN | - |
dc.subject.keywordAuthor | dissolvable microneedles | - |
dc.subject.keywordAuthor | immunomodulation | - |
dc.subject.keywordAuthor | melanoma immunotherapy | - |
dc.subject.keywordAuthor | micro-stereolithography 3D printing | - |
dc.subject.keywordAuthor | self-locking microneedles | - |
dc.subject.keywordAuthor | transcutaneous drug delivery | - |
dc.identifier.url | https://onlinelibrary.wiley.com/doi/10.1002/adma.202209966 | - |
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