Enhanced Immunogenic Cell Death by Apoptosis/Ferroptosis Hybrid Pathway Potentiates PD-L1 Blockade Cancer Immunotherapy
DC Field | Value | Language |
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dc.contributor.author | Jeong, Seong Dong | - |
dc.contributor.author | Jung, Bo-Kyeong | - |
dc.contributor.author | Lee, DaeYong | - |
dc.contributor.author | Ha, JongHoon | - |
dc.contributor.author | Chang, Han-Gyu | - |
dc.contributor.author | Lee, Jeongmin | - |
dc.contributor.author | Lee, Susam | - |
dc.contributor.author | Yun, Chae-Ok | - |
dc.contributor.author | Kim, Yeu-Chun | - |
dc.date.accessioned | 2023-05-03T11:13:44Z | - |
dc.date.available | 2023-05-03T11:13:44Z | - |
dc.date.created | 2023-01-05 | - |
dc.date.issued | 2022-12 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/185178 | - |
dc.description.abstract | Even though chemotherapy regimens for treating cancer by inducing apoptosis are extensively utilized, their therapeutic effect is hindered by multiple limitations. Thus, a combination of other types of anticancer modalities is urgently needed. Herein, a tannic acid (TA)-Fe3+-coated doxorubicin (DOX)-encapsulated 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N- [methoxy(poly(ethylene glycol))-2000] (ammonium salt) (DSPE-PEG) micelle (TFDD) for apoptosis/ferroptosis-mediated immunogenic cell death (ICD) is reported. By coating TA-Fe3+ on the surface of DOX-loaded micelles, an apoptotic agent and a ferroptotic agent are simultaneously delivered into the cancer cells and induce cell death. Furthermore, the intracellular oxidative environment generated by the apoptosis/ferroptosis hybrid pathway stimulates the endoplasmic reticulum (ER) and leads to ICD induction. The in vivo results show that the combination treatment of TFDD and anti-programmed death-ligand 1 antibodies (anti-PD-L1) considerably inhibits tumor growth and improves antitumor immunity by activating CD4+ and CD8+ T cells and decreasing the ratio of regulatory T cells (Treg) to CD4+ T cells. This study suggests that the apoptosis/ferroptosis-mediated ICD inducer may offer a potent strategy for enhanced cancer immunotherapy. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | AMER CHEMICAL SOC | - |
dc.title | Enhanced Immunogenic Cell Death by Apoptosis/Ferroptosis Hybrid Pathway Potentiates PD-L1 Blockade Cancer Immunotherapy | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Yun, Chae-Ok | - |
dc.identifier.doi | 10.1021/acsbiomaterials.2c00950 | - |
dc.identifier.scopusid | 2-s2.0-85143387976 | - |
dc.identifier.wosid | 000892245200001 | - |
dc.identifier.bibliographicCitation | ACS BIOMATERIALS SCIENCE & ENGINEERING, v.8, no.12, pp.5188 - 5198 | - |
dc.relation.isPartOf | ACS BIOMATERIALS SCIENCE & ENGINEERING | - |
dc.citation.title | ACS BIOMATERIALS SCIENCE & ENGINEERING | - |
dc.citation.volume | 8 | - |
dc.citation.number | 12 | - |
dc.citation.startPage | 5188 | - |
dc.citation.endPage | 5198 | - |
dc.type.rims | ART | - |
dc.type.docType | Article; Early Access | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Materials Science | - |
dc.relation.journalWebOfScienceCategory | Materials Science, Biomaterials | - |
dc.subject.keywordPlus | FERROPTOSIS | - |
dc.subject.keywordPlus | IRON | - |
dc.subject.keywordPlus | MECHANISMS | - |
dc.subject.keywordPlus | APOPTOSIS | - |
dc.subject.keywordAuthor | apoptosis | - |
dc.subject.keywordAuthor | ferroptosis hybrid pathway | - |
dc.subject.keywordAuthor | immunogenic cell death | - |
dc.subject.keywordAuthor | immune checkpoint blockade | - |
dc.subject.keywordAuthor | combination cancer immunotherapy | - |
dc.identifier.url | https://pubs.acs.org/doi/10.1021/acsbiomaterials.2c00950 | - |
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