Carbon quantum dots@metal–organic framework based catalytic nucleic acid fluorescent system for highly sensitive and selective detection of Pb2+ in aqueous solutions
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Jain, Shikha | - |
dc.contributor.author | Dilbaghi, Neeraj | - |
dc.contributor.author | Kumar Singhal, Nitin | - |
dc.contributor.author | Kaushik, Ajeet | - |
dc.contributor.author | Kim, Ki-Hyun | - |
dc.contributor.author | Kumar, Sandeep | - |
dc.date.accessioned | 2023-06-01T06:46:18Z | - |
dc.date.available | 2023-06-01T06:46:18Z | - |
dc.date.created | 2023-02-08 | - |
dc.date.issued | 2023-02 | - |
dc.identifier.issn | 1385-8947 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/185759 | - |
dc.description.abstract | Accumulation of heavy metal ions in the ecosystem has become a major concern due to their adverse impacts on animals, humans, and aquatic habitats. The development of a rapid and portable sensing system is important for the prompt detection and proper management of such pollutants. Herein, we have designed a fluorescence-based biosensor for the selective and sensitive detection of Pb2+ ions using a DNAzyme system that is active only in the presence of lead (II) ions (Pb2+). The developed nanoprobe relies on two major components: (i) boron and nitrogen carbon dots (BNCDs)-doped carboxyl functionalized-terbium metal-organic framework (COOH-Tb MOF) as a fluorescent tag and (ii) quencher-modified catalytic NH3-GR5 DNAzyme as a bioreceptor molecule. The fluorescent tag (BNCDs/MOF) exhibits dual fluorescence with emission peaks located in the regions of blue and green. In the absence of Pb2+ ions, this hybridization undergoes reduced emission intensity because of the overlap in fluorescence emission between BNCDs@Tb-MOF and quenchers. However, as the catalytic core of the DNAzyme strand is activated in the presence of Pb2+ ions, the fluorescent emission of BNCDs/Tb-MOF resumes with the cleavage of quencher-tagged substrate strand. Here, the release of a shorter oligo sequence effectively increases the intensity of the proposed novel biosensor to realize low level detection of Pb2+ (e.g., to 0.96 ppb in a wide detection range from 2 to 1000 nM). The establishment of this novel biosensing approach is expected to offer new insights into rapid, selective, and sensitive detection of major pollutants for food and environmental safety. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER SCIENCE SA | - |
dc.title | Carbon quantum dots@metal–organic framework based catalytic nucleic acid fluorescent system for highly sensitive and selective detection of Pb2+ in aqueous solutions | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Ki-Hyun | - |
dc.identifier.doi | 10.1016/j.cej.2023.141375 | - |
dc.identifier.scopusid | 2-s2.0-85146076089 | - |
dc.identifier.wosid | 000975188800001 | - |
dc.identifier.bibliographicCitation | CHEMICAL ENGINEERING JOURNAL, v.457, pp.1 - 13 | - |
dc.relation.isPartOf | CHEMICAL ENGINEERING JOURNAL | - |
dc.citation.title | CHEMICAL ENGINEERING JOURNAL | - |
dc.citation.volume | 457 | - |
dc.citation.startPage | 1 | - |
dc.citation.endPage | 13 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Engineering | - |
dc.relation.journalWebOfScienceCategory | Engineering, Environmental | - |
dc.relation.journalWebOfScienceCategory | Engineering, Chemical | - |
dc.subject.keywordPlus | GR-5 DNAZYME | - |
dc.subject.keywordPlus | SENSOR | - |
dc.subject.keywordPlus | WATER | - |
dc.subject.keywordPlus | IONS | - |
dc.subject.keywordPlus | LEAD | - |
dc.subject.keywordPlus | BIOSENSOR | - |
dc.subject.keywordPlus | NANOPARTICLES | - |
dc.subject.keywordPlus | PB(II) | - |
dc.subject.keywordAuthor | Quantum dots | - |
dc.subject.keywordAuthor | Fluorescence | - |
dc.subject.keywordAuthor | DNAzyme | - |
dc.subject.keywordAuthor | Metal organic framework | - |
dc.subject.keywordAuthor | Biosensor | - |
dc.identifier.url | https://www.sciencedirect.com/science/article/pii/S1385894723001067?via%3Dihub | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
222, Wangsimni-ro, Seongdong-gu, Seoul, 04763, Korea+82-2-2220-1365
COPYRIGHT © 2021 HANYANG UNIVERSITY.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.