Clinical pitfalls and serological diagnostics of MuSK myasthenia gravis
DC Field | Value | Language |
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dc.contributor.author | Kwon, Young Nam | - |
dc.contributor.author | Woodhall, Mark | - |
dc.contributor.author | Sung, Jung-Joon | - |
dc.contributor.author | Kim, Kwang-Kuk | - |
dc.contributor.author | Lim, Young-Min | - |
dc.contributor.author | Kim, Hyunjin | - |
dc.contributor.author | Kim, Jee-Eun | - |
dc.contributor.author | Baek, Seol-Hee | - |
dc.contributor.author | Kim, Byung-Jo | - |
dc.contributor.author | Park, Jin-Sung | - |
dc.contributor.author | Seok, Hung Youl | - |
dc.contributor.author | Kim, Dae-Seong | - |
dc.contributor.author | Kwon, Ohyun | - |
dc.contributor.author | Park, Kee Hong | - |
dc.contributor.author | Sohn, Eunhee | - |
dc.contributor.author | Bae, Jong Seok | - |
dc.contributor.author | Yoon, Byung-Nam | - |
dc.contributor.author | Kim, Nam-Hee | - |
dc.contributor.author | Ahn, Suk-Won | - |
dc.contributor.author | Choi, Kyomin | - |
dc.contributor.author | Oh, Jeeyoung | - |
dc.contributor.author | Park, Hyung Jun | - |
dc.contributor.author | Shin, Kyong Jin | - |
dc.contributor.author | Lee, Sanggon | - |
dc.contributor.author | Park, Jinseok | - |
dc.contributor.author | Kim, Seung Hyun | - |
dc.contributor.author | Seok, Jung Im | - |
dc.contributor.author | Bae, Dae Woong | - |
dc.contributor.author | An, Jae Young | - |
dc.contributor.author | Joo, In Soo | - |
dc.contributor.author | Choi, Seok-Jin | - |
dc.contributor.author | Nam, Tai-Seung | - |
dc.contributor.author | Kim, Sunyoung | - |
dc.contributor.author | Park, Ki-Jong | - |
dc.contributor.author | Kwon, Ki-Han | - |
dc.contributor.author | Waters, Patrick | - |
dc.contributor.author | Hong, Yoon-Ho | - |
dc.date.accessioned | 2023-06-01T06:48:14Z | - |
dc.date.available | 2023-06-01T06:48:14Z | - |
dc.date.created | 2022-12-07 | - |
dc.date.issued | 2023-03 | - |
dc.identifier.issn | 0340-5354 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/185767 | - |
dc.description.abstract | Background We aimed to evaluate the diagnostic accuracy of enzyme-linked immunosorbent assay (ELISA) for anti-muscle specific tyrosine kinase (MuSK) antibody (Ab) in a large cohort of anti-acetylcholine receptor (AChR) Ab-negative generalized myasthenia gravis (MG), and also to investigate clinical contexts for the diagnosis of MuSK MG. Methods A retrospective study of 160 patients with a clinical suspicion of AChR Ab-negative generalized MG was performed. The serum samples were tested for anti-clustered AChR Ab by cell-based assay (CBA), anti-MuSK Ab by ELISA, CBA and/or radioimmunoprecipitation assay (RIPA). Clinical data were compared between anti-MuSK Ab-positive MG and double seronegative (AChR and MuSK) MG groups. Results After excluding non-MG and clustered AChR Ab-positive patients, we identified 89 patients as a cohort of AChR Ab-negative generalized MG. Anti-MuSK Ab was positive by ELISA in 22 (24.7%) patients. While CBA identified five additional anti-MuSK Ab-positive patients, the results of ELISA were mostly consistent with CBA and RIPA with Cohen's kappa of 0.80 and 0.90, respectively (p < 0.001). The most frequent differential diagnosis was motor neuron disease particularly of bulbar onset which showed remarkably overlapping clinical and electrophysiological features with MuSK MG at presentation. Conclusion While confirming the highest sensitivity of CBA for detecting anti-MuSK Ab, our results highlight the clinical pitfalls in making a diagnosis of MuSK MG and may support a diagnostic utility of MuSK-ELISA in clinical practice. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | SPRINGER HEIDELBERG | - |
dc.title | Clinical pitfalls and serological diagnostics of MuSK myasthenia gravis | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Park, Jinseok | - |
dc.contributor.affiliatedAuthor | Kim, Seung Hyun | - |
dc.identifier.doi | 10.1007/s00415-022-11458-4 | - |
dc.identifier.scopusid | 2-s2.0-85142151342 | - |
dc.identifier.wosid | 000884957900001 | - |
dc.identifier.bibliographicCitation | JOURNAL OF NEUROLOGY, v.270, no.3, pp.1478 - 1486 | - |
dc.relation.isPartOf | JOURNAL OF NEUROLOGY | - |
dc.citation.title | JOURNAL OF NEUROLOGY | - |
dc.citation.volume | 270 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 1478 | - |
dc.citation.endPage | 1486 | - |
dc.type.rims | ART | - |
dc.type.docType | Article; Early Access | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Neurosciences & Neurology | - |
dc.relation.journalWebOfScienceCategory | Clinical Neurology | - |
dc.subject.keywordPlus | ACETYLCHOLINE-RECEPTOR | - |
dc.subject.keywordPlus | ANTIBODIES | - |
dc.subject.keywordPlus | KINASE | - |
dc.subject.keywordAuthor | Seronegative myasthenia gravis | - |
dc.subject.keywordAuthor | Anti-MuSK antibody | - |
dc.subject.keywordAuthor | ELISA | - |
dc.subject.keywordAuthor | Cell-based assay | - |
dc.subject.keywordAuthor | Radioimmunoprecipitation assay | - |
dc.identifier.url | https://link.springer.com/article/10.1007/s00415-022-11458-4 | - |
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