Biomimetic anti-inflammatory and osteogenic nanoparticles self-assembled with mineral ions and tannic acid for tissue engineering
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Byun, Hayeon | - |
dc.contributor.author | Jang, Gyu Nam | - |
dc.contributor.author | Hong, Min-Ho | - |
dc.contributor.author | Yeo, Jiwon | - |
dc.contributor.author | Shin, Hyunjung | - |
dc.contributor.author | Kim, Won Jong | - |
dc.contributor.author | Shin, Heungsoo | - |
dc.date.accessioned | 2023-06-01T06:54:34Z | - |
dc.date.available | 2023-06-01T06:54:34Z | - |
dc.date.created | 2022-11-02 | - |
dc.date.issued | 2022-10 | - |
dc.identifier.issn | 2196-5404 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/185798 | - |
dc.description.abstract | Bone healing involves complex processes including inflammation, induction, and remodeling. In this context, anti-inflammatory and osteoconductive multi-functional nanoparticles have attracted considerable attention for application in improved bone tissue regeneration. In particular, nanoparticles that promote suppression of inflammatory response after injury and direction of desirable tissue regeneration events are of immense interest to researchers. We herein report a one-step method to prepare multi-functional nanoparticles using tannic acid (TA) and simulated body fluid (SBF) containing multiple mineral ions. Mineral-tannic acid nanoparticles (mTNs) were rapidly fabricated in 10 min, and their size (around 250-350 nm) and chemical composition were controlled through the TA concentration. In vitro analysis using human adipose derived stem cells (hADSCs) showed that mTNs effectively scavenged reactive oxygen species (ROS) and enhanced osteogenesis of hADSCs by inducing secretion of alkaline phosphatase. mTNs also increased osteogenic marker gene expression even in the presence of ROS, which can generally arrest osteogenesis (OPN: 1.74, RUNX2: 1.90, OCN: 1.47-fold changes relative to cells not treated with mTNs). In vivo analysis using a mouse peritonitis model revealed that mTNs showed anti-inflammatory effects by decreasing levels of pro-inflammatory cytokines in blood (IL-6: 73 +/- 4, TNF-alpha: 42 +/- 2%) and peritoneal fluid (IL-6: 78 +/- 2, TNF-alpha: 21 +/- 6%). We believe that this one-step method for fabrication of multi-functional nanoparticles has considerable potential in tissue engineering approaches that require control of complex microenvironments, as required for tissue regeneration. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | SPRINGER | - |
dc.title | Biomimetic anti-inflammatory and osteogenic nanoparticles self-assembled with mineral ions and tannic acid for tissue engineering | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Shin, Heungsoo | - |
dc.identifier.doi | 10.1186/s40580-022-00338-2 | - |
dc.identifier.scopusid | 2-s2.0-85139748489 | - |
dc.identifier.wosid | 000865752600001 | - |
dc.identifier.bibliographicCitation | NANO CONVERGENCE, v.9, no.1, pp.1 - 12 | - |
dc.relation.isPartOf | NANO CONVERGENCE | - |
dc.citation.title | NANO CONVERGENCE | - |
dc.citation.volume | 9 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 1 | - |
dc.citation.endPage | 12 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART002959964 | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalResearchArea | Materials Science | - |
dc.relation.journalResearchArea | Physics | - |
dc.relation.journalWebOfScienceCategory | Nanoscience & Nanotechnology | - |
dc.relation.journalWebOfScienceCategory | Materials Science, Multidisciplinary | - |
dc.relation.journalWebOfScienceCategory | Physics, Applied | - |
dc.subject.keywordPlus | DIFFERENTIATION | - |
dc.subject.keywordPlus | BIOMATERIALS | - |
dc.subject.keywordPlus | POLYPHENOLS | - |
dc.subject.keywordPlus | MECHANISMS | - |
dc.subject.keywordPlus | CELLS | - |
dc.subject.keywordPlus | METAL | - |
dc.subject.keywordAuthor | Multi-functional biomaterial | - |
dc.subject.keywordAuthor | Supramolecular self-assembly | - |
dc.subject.keywordAuthor | Metal phenolic network | - |
dc.subject.keywordAuthor | Tannic acid | - |
dc.subject.keywordAuthor | Mineral nanoparticle | - |
dc.subject.keywordAuthor | Anti-inflammation | - |
dc.subject.keywordAuthor | Tissue engineering | - |
dc.identifier.url | https://nanoconvergencejournal.springeropen.com/articles/10.1186/s40580-022-00338-2 | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
222, Wangsimni-ro, Seongdong-gu, Seoul, 04763, Korea+82-2-2220-1365
COPYRIGHT © 2021 HANYANG UNIVERSITY.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.