Fas mutation reduces obesity by increasing IL-4 and IL-10 expression and promoting white adipose tissue browning
DC Field | Value | Language |
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dc.contributor.author | Choi, Eun Wha | - |
dc.contributor.author | Lee, Minjae | - |
dc.contributor.author | Song, Ji Woo | - |
dc.contributor.author | Kim, Kyeongdae | - |
dc.contributor.author | Lee, Jungmin | - |
dc.contributor.author | Yang, Jehoon | - |
dc.contributor.author | Lee, Seo Hyun | - |
dc.contributor.author | Kim, Il Yong | - |
dc.contributor.author | Choi, Jae-Hoon | - |
dc.contributor.author | Seong, Je Kyung | - |
dc.date.accessioned | 2021-07-30T04:53:24Z | - |
dc.date.available | 2021-07-30T04:53:24Z | - |
dc.date.created | 2021-05-12 | - |
dc.date.issued | 2020-07 | - |
dc.identifier.issn | 2045-2322 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/1857 | - |
dc.description.abstract | Brown adipose tissue generates heat via the mitochondrial uncoupling protein UCP1 to protect against obesity and hypothermia. Fas mutant MRL/lpr mice exhibit a significantly leaner phenotype compared to wild type MRL/MpJ mice. In this study, we evaluated the inflammatory cell population in the adipose tissue of MRL/lpr mice, which could potentially influence their lean phenotype. Furthermore, we compared beige fat activity between the MRL/MpJ and MRL/lpr mice. Fas mutation resulted in high body temperature, improved glucose tolerance, and decreased fat mass and adipocyte size. Fas mutation prevented high-fat diet-induced obesity and decreased the white adipose tissue M1:M2 ratio. When mice were fed a high-fat diet, UCP1, IL-4, IL-10, and tyrosine hydroxylase genes had significantly higher expression in Fas-mutant mice than in wild type mice. After a cold challenge, UCP1 expression and browning were also significantly higher in the Fas-mutant mice. In summary, Fas-mutant mice are resistant to high-fat diet-induced obesity due to increased IL-4 and IL-10 levels and the promotion of thermogenic protein activity and browning in their adipose tissues. STAT6 activation might contribute to M2 polarisation by increasing IL-4 and IL-10 levels while increases in M2 and tyrosine hydroxylase levels promote browning in response to Fas mutation. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | NATURE PUBLISHING GROUP | - |
dc.title | Fas mutation reduces obesity by increasing IL-4 and IL-10 expression and promoting white adipose tissue browning | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Choi, Jae-Hoon | - |
dc.identifier.doi | 10.1038/s41598-020-68971-7 | - |
dc.identifier.scopusid | 2-s2.0-85088259307 | - |
dc.identifier.wosid | 000553556900017 | - |
dc.identifier.bibliographicCitation | SCIENTIFIC REPORTS, v.10, no.1, pp.1 - 14 | - |
dc.relation.isPartOf | SCIENTIFIC REPORTS | - |
dc.citation.title | SCIENTIFIC REPORTS | - |
dc.citation.volume | 10 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 1 | - |
dc.citation.endPage | 14 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalWebOfScienceCategory | Multidisciplinary Sciences | - |
dc.subject.keywordPlus | MICE | - |
dc.subject.keywordPlus | MACROPHAGES | - |
dc.subject.keywordPlus | CELLS | - |
dc.subject.keywordPlus | TRANSPLANTATION | - |
dc.subject.keywordPlus | EOSINOPHILS | - |
dc.subject.keywordPlus | ADIPOCYTES | - |
dc.subject.keywordPlus | MECHANISMS | - |
dc.subject.keywordPlus | INJECTION | - |
dc.subject.keywordPlus | DISEASE | - |
dc.subject.keywordPlus | MOUSE | - |
dc.identifier.url | https://www.nature.com/articles/s41598-020-68971-7 | - |
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