Silencing of Glut1 induces chemoresistance via modulation of Akt/GSK-3β/β-catenin/survivin signaling pathway in breast cancer cells
DC Field | Value | Language |
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dc.contributor.author | Oh, Sunhwa | - |
dc.contributor.author | Kim, Hyungjoo | - |
dc.contributor.author | Nam, KeeSoo | - |
dc.contributor.author | Shin, Incheol | - |
dc.date.accessioned | 2021-08-02T14:27:31Z | - |
dc.date.available | 2021-08-02T14:27:31Z | - |
dc.date.created | 2021-05-12 | - |
dc.date.issued | 2017-12 | - |
dc.identifier.issn | 0003-9861 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/18605 | - |
dc.description.abstract | Cancer cells require increased aerobic glycolysis to support rapid cell proliferation. For their increased energy demands, cancer cells express glucose transporter (Glut) proteins at a high level. Glut1 is associated with basal-like breast cancer and is considered a potential therapeutic target. To investigate the possibility of Glut1 as a therapeutic target in breast cancer cells, we downregulated Glut1 in triple negative breast cancer (TNBC) cell lines using a short hairpin system. We determined whether Glut1 silencing might enhance anti-proliferative effect of chemotherapeutic agents. Contrary to our hypothesis, ablation of Glut1 attenuated apoptosis and increased drug resistance via upregulation of p-Akt/p-GSK-3 beta (Ser9)/beta-cateninisurvivin. These results indicated that the potential of Glut1 as a therapeutic target should be carefully reevaluated. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER SCIENCE INC | - |
dc.title | Silencing of Glut1 induces chemoresistance via modulation of Akt/GSK-3β/β-catenin/survivin signaling pathway in breast cancer cells | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Shin, Incheol | - |
dc.identifier.doi | 10.1016/j.abb.2017.08.009 | - |
dc.identifier.scopusid | 2-s2.0-85034650957 | - |
dc.identifier.wosid | 000418107500012 | - |
dc.identifier.bibliographicCitation | ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, v.636, pp.110 - 122 | - |
dc.relation.isPartOf | ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS | - |
dc.citation.title | ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS | - |
dc.citation.volume | 636 | - |
dc.citation.startPage | 110 | - |
dc.citation.endPage | 122 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Biophysics | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Biophysics | - |
dc.subject.keywordPlus | GLYCOGEN-SYNTHASE KINASE-3 | - |
dc.subject.keywordPlus | GROWTH-FACTOR RECEPTOR | - |
dc.subject.keywordPlus | GLUCOSE TRANSPORTERS | - |
dc.subject.keywordPlus | COLORECTAL-CANCER | - |
dc.subject.keywordPlus | EGR-1 EXPRESSION | - |
dc.subject.keywordPlus | GENE-EXPRESSION | - |
dc.subject.keywordPlus | SUGAR-TRANSPORT | - |
dc.subject.keywordPlus | POOR-PROGNOSIS | - |
dc.subject.keywordPlus | CARCINOMA | - |
dc.subject.keywordPlus | SURVIVIN | - |
dc.subject.keywordAuthor | Glut1 | - |
dc.subject.keywordAuthor | Chemoresistance | - |
dc.subject.keywordAuthor | Triple-negative breast cancer | - |
dc.identifier.url | https://www.sciencedirect.com/science/article/pii/S0003986117302631?via%3Dihub | - |
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