Diversity of binary toxin positive Clostridioides difficile in Korea
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Jieun | - |
dc.contributor.author | Kim, Bongyoung | - |
dc.contributor.author | Pai, Hyunjoo | - |
dc.date.accessioned | 2023-07-05T02:34:38Z | - |
dc.date.available | 2023-07-05T02:34:38Z | - |
dc.date.created | 2023-02-08 | - |
dc.date.issued | 2023-01 | - |
dc.identifier.issn | 2045-2322 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/186072 | - |
dc.description.abstract | The objective of this study is to determine the trend and diversity of binary toxin-positive Clostridioides difficile over 10 years in Korea. Binary toxin-positive strains were selected from a tertiary hospital in Korea in 2009–2018. The multi-locus sequence typing and antibiotic susceptibility test were performed. Among the 3278 isolates in 2009–2018, 58 possessed binary toxin genes (1.7%). The proportion of CDT- positive isolates was 0.51–4.82% in 2009–2018, which increased over the 10-year period (P = 0.023). Thirteen sequence types (STs) were identified; ST5 (14 [24%]), ST11 (11 [19%]), ST221 (10 [17%]), ST201 (7 [12%]) and ST1 (5 [9%]) were popular. All 58 isolates were susceptible to vancomycin and piperacillin/tazobactam, and clindamycin and moxifloxacin were active in 69.0% and 62% of isolates, respectively. ST1 strains were resistant to several antibiotics, including moxifloxacin (80%), clindamycin (60%) and rifaximin (60%). Moreover, four of five ST1 presented a metronidazole minimum inhibitory concentration of 4 µg/mL. Moxifloxacin resistance was highest (72.3%) for ST11. In conclusion, binary toxin-positive strains are non-prevalent in Korea and involve diverse STs. ST1 strains were resistant to several antibiotics. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | NATURE PORTFOLIO | - |
dc.title | Diversity of binary toxin positive Clostridioides difficile in Korea | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Jieun | - |
dc.contributor.affiliatedAuthor | Kim, Bongyoung | - |
dc.contributor.affiliatedAuthor | Pai, Hyunjoo | - |
dc.identifier.doi | 10.1038/s41598-023-27768-0 | - |
dc.identifier.scopusid | 2-s2.0-85146140717 | - |
dc.identifier.wosid | 000986510100029 | - |
dc.identifier.bibliographicCitation | SCIENTIFIC REPORTS, v.13, no.1, pp.1 - 6 | - |
dc.relation.isPartOf | SCIENTIFIC REPORTS | - |
dc.citation.title | SCIENTIFIC REPORTS | - |
dc.citation.volume | 13 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 1 | - |
dc.citation.endPage | 6 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalWebOfScienceCategory | Multidisciplinary Sciences | - |
dc.subject.keywordPlus | PCR RIBOTYPE 027 | - |
dc.subject.keywordPlus | STRAIN | - |
dc.subject.keywordPlus | EPIDEMIOLOGY | - |
dc.subject.keywordPlus | INFECTION | - |
dc.subject.keywordPlus | REGION | - |
dc.subject.keywordPlus | HUMANS | - |
dc.identifier.url | https://www.nature.com/articles/s41598-023-27768-0 | - |
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