Integrative analysis of DNA methylation and gene expression identifies genes associated with biological aging in Alzheimer's disease
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Bo-Hyun | - |
dc.contributor.author | Vasanthakumar, Aparna | - |
dc.contributor.author | Li, Qingqin S. | - |
dc.contributor.author | Nudelman, Kelly N. H. | - |
dc.contributor.author | Risacher, Shannon L. | - |
dc.contributor.author | Davis, Justin W. | - |
dc.contributor.author | Idler, Kenneth | - |
dc.contributor.author | Lee, Jong-Min | - |
dc.contributor.author | Seo, Sang Won | - |
dc.contributor.author | Waring, Jeffrey F. | - |
dc.contributor.author | Saykin, Andrew J. | - |
dc.contributor.author | Nho, Kwangsik | - |
dc.date.accessioned | 2023-07-05T02:40:47Z | - |
dc.date.available | 2023-07-05T02:40:47Z | - |
dc.date.created | 2022-10-06 | - |
dc.date.issued | 2022-08 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/186112 | - |
dc.description.abstract | Introduction The acceleration of biological aging is a risk factor for Alzheimer's disease (AD). Here, we performed weighted gene co-expression network analysis (WGCNA) to identify modules and dysregulated genesinvolved in biological aging in AD. Methods We performed WGCNA to identify modules associated with biological clocks and hub genes of the module with the highest module significance. In addition, we performed differential expression analysis and association analysis with AD biomarkers. Results WGCNA identified five modules associated with biological clocks, with the module designated as "purple" showing the strongest association. Functional enrichment analysis revealed that the purple module was related to cell migration and death. Ten genes were identified as hub genes in purple modules, of which CX3CR1 was downregulated in AD and low levels of CX3CR1 expression were associated with AD biomarkers. Conclusion Network analysis identified genes associated with biological clocks, which suggests the genetic architecture underlying biological aging in AD. Highlights Examine links between Alzheimer's disease (AD) peripheral transcriptome and biological aging changes. Weighted gene co-expression network analysis (WGCNA) found five modules related to biological aging. Among the hub genes of the module, CX3CR1 was downregulated in AD. The CX3CR1 expression level was associated with cognitive performance and brain atrophy. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | WILEY | - |
dc.title | Integrative analysis of DNA methylation and gene expression identifies genes associated with biological aging in Alzheimer's disease | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Lee, Jong-Min | - |
dc.identifier.doi | 10.1002/dad2.12354 | - |
dc.identifier.scopusid | 2-s2.0-85145084886 | - |
dc.identifier.bibliographicCitation | ALZHEIMER'S & DEMENTIA: DIAGNOSIS, ASSESSMENT & DISEASE MONITORING, v.14, no.1, pp.1 - 13 | - |
dc.relation.isPartOf | ALZHEIMER'S & DEMENTIA: DIAGNOSIS, ASSESSMENT & DISEASE MONITORING | - |
dc.citation.title | ALZHEIMER'S & DEMENTIA: DIAGNOSIS, ASSESSMENT & DISEASE MONITORING | - |
dc.citation.volume | 14 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 1 | - |
dc.citation.endPage | 13 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Neurosciences & Neurology | - |
dc.relation.journalWebOfScienceCategory | Clinical Neurology | - |
dc.relation.journalWebOfScienceCategory | Neurosciences | - |
dc.subject.keywordPlus | chemokine receptor CX3CR1 antagonist | - |
dc.subject.keywordPlus | perforin | - |
dc.subject.keywordPlus | aged | - |
dc.subject.keywordPlus | aging | - |
dc.subject.keywordPlus | Alzheimer disease | - |
dc.subject.keywordPlus | Article | - |
dc.subject.keywordPlus | bioinformatics | - |
dc.subject.keywordPlus | biological rhythm | - |
dc.subject.keywordPlus | cell composition | - |
dc.subject.keywordPlus | cell migration | - |
dc.subject.keywordPlus | clock drawing test | - |
dc.subject.keywordPlus | differential expression analysis | - |
dc.subject.keywordPlus | DNA methylation | - |
dc.subject.keywordPlus | female | - |
dc.subject.keywordPlus | functional enrichment analysis | - |
dc.subject.keywordPlus | gene expression | - |
dc.subject.keywordPlus | genetic transcription | - |
dc.subject.keywordPlus | human | - |
dc.subject.keywordPlus | major clinical study | - |
dc.subject.keywordPlus | male | - |
dc.subject.keywordPlus | mental performance | - |
dc.subject.keywordPlus | mild cognitive impairment | - |
dc.subject.keywordPlus | Mini Mental State Examination | - |
dc.subject.keywordPlus | network analysis | - |
dc.subject.keywordPlus | nuclear magnetic resonance imaging | - |
dc.subject.keywordPlus | protein protein interaction | - |
dc.subject.keywordPlus | quality control | - |
dc.subject.keywordPlus | T1 weighted imaging | - |
dc.subject.keywordPlus | telomere length | - |
dc.subject.keywordPlus | trail making test | - |
dc.subject.keywordPlus | weighted gene co expression network analysis | - |
dc.subject.keywordAuthor | Alzheimer&apos | - |
dc.subject.keywordAuthor | s disease | - |
dc.subject.keywordAuthor | AD biomarker | - |
dc.subject.keywordAuthor | biological aging | - |
dc.subject.keywordAuthor | CX3CR1 | - |
dc.subject.keywordAuthor | epigenetic clocks | - |
dc.subject.keywordAuthor | telomere length | - |
dc.subject.keywordAuthor | weighted gene co-expression network analysis (WGCNA) | - |
dc.identifier.url | https://alz-journals.onlinelibrary.wiley.com/doi/10.1002/dad2.12354 | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
222, Wangsimni-ro, Seongdong-gu, Seoul, 04763, Korea+82-2-2220-1365
COPYRIGHT © 2021 HANYANG UNIVERSITY.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.