Micro-ultrasonic Assessment of Early Stage Clot Formation and Whole Blood Coagulation Using an All-Optical Ultrasound Transducer and Adaptive Signal Processing Algorithm
DC Field | Value | Language |
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dc.contributor.author | Biswas, Deblina | - |
dc.contributor.author | Heo, Jeongmin | - |
dc.contributor.author | Sang, Pilgyu | - |
dc.contributor.author | Dey, Prasanta | - |
dc.contributor.author | Han, Kayoung | - |
dc.contributor.author | Ko, Jong Hwan | - |
dc.contributor.author | Won, Sang Min | - |
dc.contributor.author | Son, Donghee | - |
dc.contributor.author | Suh, Minah | - |
dc.contributor.author | Kim, Hyung Sik | - |
dc.contributor.author | Ok, Jong G. | - |
dc.contributor.author | Park, Hui Joon | - |
dc.contributor.author | Baac, Hyoung Won | - |
dc.date.accessioned | 2023-07-05T02:41:55Z | - |
dc.date.available | 2023-07-05T02:41:55Z | - |
dc.date.created | 2022-10-06 | - |
dc.date.issued | 2022-09 | - |
dc.identifier.issn | 2379-3694 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/186117 | - |
dc.description.abstract | Abnormal formation of solid thrombus inside a blood vessel can cause thrombotic morbidity and mortality. This necessitates early stage diagnosis, which requires quantitative assessment with a small volume, for effective therapy with low risk to unwanted development of various diseases. We propose a micro-ultrasonic diagnosis using an all-optical ultrasound-based spectral sensing (AOUSS) technique for sensitive and quantitati. characterization of early stage and whole blood coagulation. The AOUSS technique detects and analyzes minute viscoelastic variations of blood at a micro-ultrasonic spot (<100 mu m) defined by laser-generated focused ultrasound (LGFU). This utilizes (1) a uniquely designed optical transducer configuration for frequency-spectral matching and wideband operation (6 dB widths: 7-32 MHz and d.c. similar to 46 MHz, respectively) and (2) an empirical mode decomposition (EMD)-based signal process particularly adapted to nonstationary LGFU signals backscattered from the spot. An EMD-derived spectral analysis enables one to assess viscoelastic variations during the initiation of fibrin formation, which occurs at a very early stage of blood coagulation (1 min) with high sensitivity (frequency transition per storage modulus increment = 8.81 MHz/MPa). Our results exhibit strong agreement with those obtained by conventional rheometry (Pearson's R > 0.95), which are also confirmed by optical microscopy. The micro-ultrasonic and high-sensitivity detection of AOUSS poses a potential clinical significance, serving as a screening modality to diagnose early stage clot formation (e.g., as an indicator for hypercoagul ation of blood) and stages of blood-to-clot transition to check a potential risk for development into thrombotic diseases. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | AMER CHEMICAL SOC | - |
dc.title | Micro-ultrasonic Assessment of Early Stage Clot Formation and Whole Blood Coagulation Using an All-Optical Ultrasound Transducer and Adaptive Signal Processing Algorithm | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Park, Hui Joon | - |
dc.identifier.doi | 10.1021/acssensors.2c00875 | - |
dc.identifier.scopusid | 2-s2.0-85139169808 | - |
dc.identifier.wosid | 000856573000001 | - |
dc.identifier.bibliographicCitation | ACS SENSORS, v.7, no.10, pp.2940 - 2950 | - |
dc.relation.isPartOf | ACS SENSORS | - |
dc.citation.title | ACS SENSORS | - |
dc.citation.volume | 7 | - |
dc.citation.number | 10 | - |
dc.citation.startPage | 2940 | - |
dc.citation.endPage | 2950 | - |
dc.type.rims | ART | - |
dc.type.docType | Article; Early Access | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Multidisciplinary | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Analytical | - |
dc.relation.journalWebOfScienceCategory | Nanoscience & Nanotechnology | - |
dc.subject.keywordPlus | EMPIRICAL MODE DECOMPOSITION | - |
dc.subject.keywordPlus | GENERATED FOCUSED ULTRASOUND | - |
dc.subject.keywordPlus | WAVELET TRANSFORM | - |
dc.subject.keywordPlus | ELASTOGRAPHY | - |
dc.subject.keywordPlus | THROMBOELASTOGRAPHY | - |
dc.subject.keywordPlus | SHEAR | - |
dc.subject.keywordPlus | DIAGNOSIS | - |
dc.subject.keywordAuthor | blood coagulation | - |
dc.subject.keywordAuthor | all-optical ultrasound | - |
dc.subject.keywordAuthor | laser-generated focused ultrasound | - |
dc.subject.keywordAuthor | empirical mode decomposition | - |
dc.subject.keywordAuthor | viscoelasticity | - |
dc.identifier.url | https://pubs.acs.org/doi/10.1021/acssensors.2c00875 | - |
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