Circulatory disturbance of the cochlear spiral modiolar artery in a type 2 diabetic mouse model
DC Field | Value | Language |
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dc.contributor.author | Seo, Young Joon | - |
dc.contributor.author | Shim, Dae Bo | - |
dc.contributor.author | Sharif, Arazu | - |
dc.contributor.author | Samson, Zeke | - |
dc.contributor.author | Takechi, Ryu | - |
dc.contributor.author | Brown, Daniel | - |
dc.date.accessioned | 2023-07-05T02:42:43Z | - |
dc.date.available | 2023-07-05T02:42:43Z | - |
dc.date.created | 2022-10-06 | - |
dc.date.issued | 2022-10 | - |
dc.identifier.issn | 2378-8038 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/186121 | - |
dc.description.abstract | Objective This study aimed to identify significant differences in cochlea microvessel size between a diabetic mouse model (db/db) and normal mice using three-dimensional (3D) quantitative analysis. Methods Six control heterozygote db/+ as well as 18 male B6/BKS(D)-Lepr(db)/J (db/db) mice aged 14 (n = 9) and 28 (n = 9) weeks were examined. After clearing the cochlea, we reconstructed the 3D volumes of the spiral modiolar artery (SMA) in the cochlea using light-sheet microscopy and analyzed vessel wall thickness, cross-sectional area, short and long diameter, and vessel height. Results The average SMA-wall thickness in the db/db-mouse group (3.418 +/- 0.328 mu m) was greater than that in the control group (2.388 +/- 0.411 mu m). The average cross-sectional outer area, short diameter, and long diameter of the SMA in db/db mice were significantly larger than those in control mice (all p < 0.001). The cross-sectional areas increased with age (control: 221.782 +/- 121.230 mu m, 14 weeks; 294.378 +/- 151.008 mu m, and 28 weeks; 312.925 +/- 147.943 mu m). Conclusion The db/db mice had thicker and larger proximal-SMA vessel walls and diameters than control mice, respectively, thus potentially inducing increased blood viscosity or vascular insufficiency and aggravating hearing loss in type 2 diabetes mellitus. Level of Evidence IIb | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | WILEY | - |
dc.title | Circulatory disturbance of the cochlear spiral modiolar artery in a type 2 diabetic mouse model | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Shim, Dae Bo | - |
dc.identifier.doi | 10.1002/lio2.917 | - |
dc.identifier.scopusid | 2-s2.0-85137607401 | - |
dc.identifier.wosid | 000851503500001 | - |
dc.identifier.bibliographicCitation | LARYNGOSCOPE INVESTIGATIVE OTOLARYNGOLOGY, v.7, no.5, pp.1568 - 1574 | - |
dc.relation.isPartOf | LARYNGOSCOPE INVESTIGATIVE OTOLARYNGOLOGY | - |
dc.citation.title | LARYNGOSCOPE INVESTIGATIVE OTOLARYNGOLOGY | - |
dc.citation.volume | 7 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 1568 | - |
dc.citation.endPage | 1574 | - |
dc.type.rims | ART | - |
dc.type.docType | Article; Early Access | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Otorhinolaryngology | - |
dc.relation.journalWebOfScienceCategory | Otorhinolaryngology | - |
dc.subject.keywordPlus | SHEET FLUORESCENCE MICROSCOPY | - |
dc.subject.keywordPlus | HEARING-LOSS | - |
dc.subject.keywordPlus | LEPTIN | - |
dc.subject.keywordAuthor | db | - |
dc.subject.keywordAuthor | db mice | - |
dc.subject.keywordAuthor | diabetes mellitus | - |
dc.subject.keywordAuthor | hearing loss | - |
dc.subject.keywordAuthor | light sheet microscopy | - |
dc.subject.keywordAuthor | spiral modiolar artery | - |
dc.identifier.url | https://onlinelibrary.wiley.com/doi/10.1002/lio2.917 | - |
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