Body weight variability and the risk of dementia in patients with type 2 diabetes mellitus: A nationwide cohort study in Korea
DC Field | Value | Language |
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dc.contributor.author | Park, Kye-Yeung | - |
dc.contributor.author | Nam, Ga Eun | - |
dc.contributor.author | Han, Kyungdo | - |
dc.contributor.author | Hwang, Hwan Sik | - |
dc.date.accessioned | 2023-07-05T03:29:17Z | - |
dc.date.available | 2023-07-05T03:29:17Z | - |
dc.date.created | 2022-09-08 | - |
dc.date.issued | 2022-08 | - |
dc.identifier.issn | 0168-8227 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/186153 | - |
dc.description.abstract | Aims: This study aimed to examine the association between body weight variability and dementia risk using a large-scale cohort data of Korean patients with type 2 diabetes mellitus (T2DM). Methods: A population-based cohort of 1,206,764 individuals with T2DM aged ≥ 40 years who underwent ≥ 3 Korean national health screenings were followed up until the end of 2019. Body weight variability was assessed using variability independent of the mean (VIM). A multivariate Cox proportional hazard regression was performed with calculating hazard ratios (HRs) with 95 % confidence intervals (CIs) of dementia incidence. Results: During a median follow-up of 7.9 years, 162,615 (13.4 %) individuals developed dementia. Individuals with greater body weight variability tended to be associated with higher risk of all types of dementia (P for trend < 0.001). Individuals in the highest quartile of VIM showed 26 % (HR: 1.26, 95 % CI: 1.24–1.28), 33 % (HR: 1.33, 95 % CI: 1.30–1.36) and 28 % (HR: 1.28, 95 % CI: 1.23–1.33) higher risk for all-cause dementia, Alzheimer's disease, and vascular dementia, compared with those in the lowest quartile. These associations persisted in all body mass index categories (P for trend < 0.001). Conclusions: Maintaining an appropriate body weight may help mitigate dementia risk in patients with T2DM. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | Elsevier Ireland Ltd | - |
dc.title | Body weight variability and the risk of dementia in patients with type 2 diabetes mellitus: A nationwide cohort study in Korea | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Hwang, Hwan Sik | - |
dc.identifier.doi | 10.1016/j.diabres.2022.110015 | - |
dc.identifier.scopusid | 2-s2.0-85136337995 | - |
dc.identifier.wosid | 000862757000005 | - |
dc.identifier.bibliographicCitation | Diabetes Research and Clinical Practice, v.190, pp.1 - 7 | - |
dc.relation.isPartOf | Diabetes Research and Clinical Practice | - |
dc.citation.title | Diabetes Research and Clinical Practice | - |
dc.citation.volume | 190 | - |
dc.citation.startPage | 1 | - |
dc.citation.endPage | 7 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Endocrinology & Metabolism | - |
dc.relation.journalWebOfScienceCategory | Endocrinology & Metabolism | - |
dc.subject.keywordPlus | BRAIN INSULIN-RESISTANCE | - |
dc.subject.keywordPlus | ALZHEIMERS-DISEASE | - |
dc.subject.keywordPlus | COGNITIVE DECLINE | - |
dc.subject.keywordPlus | BLOOD-PRESSURE | - |
dc.subject.keywordPlus | INTERVENTION | - |
dc.subject.keywordPlus | OBESITY | - |
dc.subject.keywordPlus | PROGRESSION | - |
dc.subject.keywordPlus | OUTCOMES | - |
dc.subject.keywordPlus | MIDLIFE | - |
dc.subject.keywordPlus | IMPACT | - |
dc.subject.keywordAuthor | Body weight | - |
dc.subject.keywordAuthor | Body weight variability | - |
dc.subject.keywordAuthor | Type 2 diabetes mellitus | - |
dc.subject.keywordAuthor | Dementia | - |
dc.subject.keywordAuthor | Cohort study | - |
dc.identifier.url | https://www.sciencedirect.com/science/article/pii/S0168822722008294?via%3Dihub | - |
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