Non-Enzymatic Sensing of Hydrogen Peroxide Using Directly Deposited Au Nanoparticles on Solid-Supported Phospholipid Film

Abstract

Solid-supported 1,2-bis(10,12-tricosadiynoyl)-sn-glycero-3-phosphocholine (DiynePC) was used as a substrate for spontaneous formation of Au nanoparticles (AuNPs) by direction deposition of the metal onto the DiynePC monolayer. The AuNP-modified DiynePC sensor exhibited a strong catalytic activity for non-enzymatic sensing of H₂O₂ with a sensitivity of 193 μA mM⁻¹cm⁻² and limit of detection of 6.8 μM. The AuNP-modified DiynePC sensor also exhibited good selectivity and reproducibility. This work demonstrates that the solid supported DiynePC monolayer can be used to quickly screen and identify candidate catalyst materials for non-enzymatic sensing of H₂O₂ (or other analytes such as glucose) through spontaneous formation of metal nanoparticles.