Bioinspired DNase-I-Coated Melanin-Like Nanospheres for Modulation of Infection-Associated NETosis Dysregulation
DC Field | Value | Language |
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dc.contributor.author | Park, Hee Ho | - |
dc.contributor.author | Park, Wooram | - |
dc.contributor.author | Lee, Yun Young | - |
dc.contributor.author | Kim Hyelim | - |
dc.contributor.author | Seo, Hee Seung | - |
dc.contributor.author | Choi, Dong Wook | - |
dc.contributor.author | Kwon, Ho-Keun | - |
dc.contributor.author | Na, Dong Hee | - |
dc.contributor.author | Kim, Tae-Hyung | - |
dc.contributor.author | Choy, Young Bin | - |
dc.contributor.author | Ahn, June Hong | - |
dc.contributor.author | Lee, Wonhwa | - |
dc.contributor.author | Park, Chun Gwon | - |
dc.date.accessioned | 2023-07-24T09:25:26Z | - |
dc.date.available | 2023-07-24T09:25:26Z | - |
dc.date.created | 2023-07-19 | - |
dc.date.issued | 2020-12 | - |
dc.identifier.issn | 2198-3844 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/187326 | - |
dc.description.abstract | The current outbreak of the beta-coronavirus (beta-Cov) severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) began in December 2019. No specific antiviral treatments or vaccines are currently available. A recent study has reported that coronavirus disease 2019 (COVID-19), the disease caused by SARS-CoV-2 infection, is associated with neutrophil-specific plasma membrane rupture, and release excessive neutrophil extracellular traps (NETs) and extracellular DNAs (eDNAs). This mechanism involves the activation of NETosis, a neutrophil-specific programmed cell death, which is believed to play a crucial role in COVID-19 pathogenesis. Further progression of the disease can cause uncontrolled inflammation, leading to the initiation of cytokine storms, acute respiratory distress syndrome (ARDS), and sepsis. Herein, it is reported that DNase-I-coated melanin-like nanospheres (DNase-I pMNSs) mitigate sepsis-associated NETosis dysregulation, thereby preventing further progression of the disease. Recombinant DNase-I and poly(ethylene glycol) (PEG) are used as coatings to promote the lengthy circulation and dissolution of NET structure. The data indicate that the application of bioinspired DNase-I pMNSs reduce neutrophil counts and NETosis-related factors in the plasma of SARS-CoV-2 sepsis patients, alleviates systemic inflammation, and attenuates mortality in a septic mouse model. Altogether, the findings suggest that these nanoparticles have potential applications in the treatment of SARS-CoV-2-related illnesses and other beta-CoV-related diseases. | - |
dc.publisher | WILEY | - |
dc.title | Bioinspired DNase-I-Coated Melanin-Like Nanospheres for Modulation of Infection-Associated NETosis Dysregulation | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Park, Hee Ho | - |
dc.identifier.doi | 10.1002/advs.202001940 | - |
dc.identifier.scopusid | 2-s2.0-85092727857 | - |
dc.identifier.wosid | 000579391400001 | - |
dc.identifier.bibliographicCitation | ADVANCED SCIENCE, v.7, no.23, pp.1 - 10 | - |
dc.relation.isPartOf | ADVANCED SCIENCE | - |
dc.citation.title | ADVANCED SCIENCE | - |
dc.citation.volume | 7 | - |
dc.citation.number | 23 | - |
dc.citation.startPage | 1 | - |
dc.citation.endPage | 10 | - |
dc.type.rims | ART | - |
dc.type.docType | 정기학술지(Article(Perspective Article포함)) | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalResearchArea | Materials Science | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Multidisciplinary | - |
dc.relation.journalWebOfScienceCategory | Nanoscience & Nanotechnology | - |
dc.relation.journalWebOfScienceCategory | Materials Science, Multidisciplinary | - |
dc.subject.keywordPlus | NEUTROPHIL EXTRACELLULAR TRAPS | - |
dc.subject.keywordPlus | SEPSIS | - |
dc.subject.keywordPlus | SURVIVAL | - |
dc.subject.keywordAuthor | Bioinspiration | - |
dc.subject.keywordAuthor | COVID-19 | - |
dc.subject.keywordAuthor | DNase-I | - |
dc.subject.keywordAuthor | Nanospheres | - |
dc.subject.keywordAuthor | NETosis | - |
dc.identifier.url | https://onlinelibrary.wiley.com/doi/10.1002/advs.202001940 | - |
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