COVID-19-activated SREBP2 disturbs cholesterol biosynthesis and leads to cytokine storm
DC Field | Value | Language |
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dc.contributor.author | Lee, Wonhwa | - |
dc.contributor.author | Ahn, June Hong | - |
dc.contributor.author | Park, Hee Ho | - |
dc.contributor.author | Kim, Hong Nam | - |
dc.contributor.author | Kim, Hyelim | - |
dc.contributor.author | Yoo, Youngbum | - |
dc.contributor.author | Shin, Hyosoo | - |
dc.contributor.author | Hong, Kyung Soo | - |
dc.contributor.author | Jang, Jong Geol | - |
dc.contributor.author | Park, Chun Gwon | - |
dc.contributor.author | Choi, Eun Young | - |
dc.contributor.author | Bae, Jong-Sup | - |
dc.contributor.author | Seo, Young-Kyo | - |
dc.date.accessioned | 2023-07-24T09:27:01Z | - |
dc.date.available | 2023-07-24T09:27:01Z | - |
dc.date.created | 2023-07-19 | - |
dc.date.issued | 2020-09 | - |
dc.identifier.issn | 2095-9907 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/187332 | - |
dc.description.abstract | Sterol regulatory element binding protein-2 (SREBP-2) is activated by cytokines or pathogen, such as virus or bacteria, but its association with diminished cholesterol levels in COVID-19 patients is unknown. Here, we evaluated SREBP-2 activation in peripheral blood mononuclear cells of COVID-19 patients and verified the function of SREBP-2 in COVID-19. Intriguingly, we report the first observation of SREBP-2 C-terminal fragment in COVID-19 patients' blood and propose SREBP-2 C-terminal fragment as an indicator for determining severity. We confirmed that SREBP-2-induced cholesterol biosynthesis was suppressed by Sestrin-1 and PCSK9 expression, while the SREBP-2-induced inflammatory responses was upregulated in COVID-19 ICU patients. Using an infectious disease mouse model, inhibitors of SREBP-2 and NF-kappa B suppressed cytokine storms caused by viral infection and prevented pulmonary damages. These results collectively suggest that SREBP-2 can serve as an indicator for severity diagnosis and therapeutic target for preventing cytokine storm and lung damage in severe COVID-19 patients. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | SPRINGERNATURE | - |
dc.title | COVID-19-activated SREBP2 disturbs cholesterol biosynthesis and leads to cytokine storm | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Park, Hee Ho | - |
dc.identifier.doi | 10.1038/s41392-020-00292-7 | - |
dc.identifier.scopusid | 2-s2.0-85090109529 | - |
dc.identifier.wosid | 000569773700003 | - |
dc.identifier.bibliographicCitation | SIGNAL TRANSDUCTION AND TARGETED THERAPY, v.5, no.1, pp.1 - 11 | - |
dc.relation.isPartOf | SIGNAL TRANSDUCTION AND TARGETED THERAPY | - |
dc.citation.title | SIGNAL TRANSDUCTION AND TARGETED THERAPY | - |
dc.citation.volume | 5 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 1 | - |
dc.citation.endPage | 11 | - |
dc.type.rims | ART | - |
dc.type.docType | 정기학술지(Article(Perspective Article포함)) | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Cell Biology | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Cell Biology | - |
dc.subject.keywordPlus | COVID-19 | - |
dc.subject.keywordPlus | TRANSCRIPTION | - |
dc.subject.keywordPlus | SUPPRESSES | - |
dc.subject.keywordPlus | METABOLISM | - |
dc.subject.keywordPlus | PATHWAYS | - |
dc.subject.keywordPlus | BINDING | - |
dc.subject.keywordPlus | PROTEIN | - |
dc.subject.keywordPlus | SEPSIS | - |
dc.subject.keywordPlus | MTORC1 | - |
dc.subject.keywordPlus | GENES | - |
dc.identifier.url | https://www.nature.com/articles/s41392-020-00292-7 | - |
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