Bisphenol A induces COX-2 through the mitogen-activated protein kinase pathway and is associated with levels of inflammation-related markers in elderly populations
DC Field | Value | Language |
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dc.contributor.author | Song, Heewon | - |
dc.contributor.author | Park, Joonwoo | - |
dc.contributor.author | Bui, Phuong T. C. | - |
dc.contributor.author | Choi, KeunOh | - |
dc.contributor.author | Gye, Myung Chan | - |
dc.contributor.author | Hong, Yun-Chul | - |
dc.contributor.author | Kim, Jin Hee | - |
dc.contributor.author | Lee, Young Joo | - |
dc.date.accessioned | 2021-08-02T14:29:05Z | - |
dc.date.available | 2021-08-02T14:29:05Z | - |
dc.date.created | 2021-05-12 | - |
dc.date.issued | 2017-10 | - |
dc.identifier.issn | 0013-9351 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/18735 | - |
dc.description.abstract | Bisphenol A (BPA) is a well-known endocrine-disrupting chemical, and it is one of the highest volume chemicals produced worldwide. Even though several in vivo and in vitro studies showed positive associations of BPA exposure with pro-inflammatory cytokines such as tumor necrosis factor-alpha and interleukin (IL)-6, the mechanism by which BPA induces inflammation is unclear. We investigated the mechanism by which BPA induces inflammation (expression of inflammation-related genes, changes in oxidative stress, and cell proliferation and migration) and evaluated the effect of BPA exposure on inflammation-related markers in epidemiologic studies using repeat urine and serum samples from elderly subjects. BPA induced COX-2 expression via nuclear translocation of NF-kappa B and activation of mitogen-activated protein kinase (MAPK) by phosphorylation of ERK1/2 and enhanced the migration of lung cancer A549 and breast cancer MDAMB-231 cells. In two epidemiologic studies, we detected associations of BPA with six inflammation -related markers (WBC, CRP, IL-10, ALT, AST, and gamma-GTP levels). Our findings probably suggest that BPA exposure induces inflammation and exacerbates tumorigenesis. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | ACADEMIC PRESS INC ELSEVIER SCIENCE | - |
dc.title | Bisphenol A induces COX-2 through the mitogen-activated protein kinase pathway and is associated with levels of inflammation-related markers in elderly populations | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Gye, Myung Chan | - |
dc.identifier.doi | 10.1016/j.envres.2017.07.005 | - |
dc.identifier.scopusid | 2-s2.0-85021897886 | - |
dc.identifier.wosid | 000408184700055 | - |
dc.identifier.bibliographicCitation | ENVIRONMENTAL RESEARCH, v.158, pp.490 - 498 | - |
dc.relation.isPartOf | ENVIRONMENTAL RESEARCH | - |
dc.citation.title | ENVIRONMENTAL RESEARCH | - |
dc.citation.volume | 158 | - |
dc.citation.startPage | 490 | - |
dc.citation.endPage | 498 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Environmental Sciences & Ecology | - |
dc.relation.journalResearchArea | Public, Environmental & Occupational Health | - |
dc.relation.journalWebOfScienceCategory | Environmental Sciences | - |
dc.relation.journalWebOfScienceCategory | Public, Environmental & Occupational Health | - |
dc.subject.keywordPlus | NF-KAPPA-B | - |
dc.subject.keywordPlus | INSULIN-RESISTANCE | - |
dc.subject.keywordPlus | OXIDATIVE STRESS | - |
dc.subject.keywordPlus | EXPOSURE | - |
dc.subject.keywordPlus | CANCER | - |
dc.subject.keywordPlus | CYCLOOXYGENASE-2 | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | INVOLVEMENT | - |
dc.subject.keywordPlus | MECHANISMS | - |
dc.subject.keywordPlus | MIGRATION | - |
dc.subject.keywordAuthor | Bisphenol A | - |
dc.subject.keywordAuthor | Inflammation | - |
dc.subject.keywordAuthor | COX-2 expression | - |
dc.subject.keywordAuthor | Epidemiology | - |
dc.identifier.url | https://www.sciencedirect.com/science/article/pii/S001393511730316X?via%3Dihub | - |
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