Insights into the selective bactericidal activity of W(Mo)Se2 nanosheets for therapy of pathogenic bacterial infections
DC Field | Value | Language |
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dc.contributor.author | So, Yoonhee | - |
dc.contributor.author | Yim, DaBin | - |
dc.contributor.author | Lee, Sin | - |
dc.contributor.author | Lee, Hyunji | - |
dc.contributor.author | Kim, Hongwon | - |
dc.contributor.author | Yu, Yejoo | - |
dc.contributor.author | Choi, Chanhee | - |
dc.contributor.author | Kim, Jong-Ho | - |
dc.date.accessioned | 2023-07-24T09:49:07Z | - |
dc.date.available | 2023-07-24T09:49:07Z | - |
dc.date.created | 2023-07-10 | - |
dc.date.issued | 2023-07 | - |
dc.identifier.issn | 1385-8947 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/187480 | - |
dc.description.abstract | The abuse and misuse of broad-spectrum antibiotics cause drug resistance in bacteria, which compromises their benefits and thereby increases the demand for new bactericidal mechanisms to reduce the emergence of multidrug-resistant pathogenic bacteria. Herein, ultrathin WSe2 and MoSe2 nanosheets are exfoliated and functionalized with poly(acrylic acid) (PAA) (PAA-WSe2 and PAA-MoSe2) in an aqueous solution as narrow-spectrum or species-specific antibiotics for the treatment of bacterial infections. PAA-WSe2 nanosheets exhibit narrow-spectrum bactericidal activity with low minimum inhibitory concentrations only for gram-positive bacteria, including multidrug-resistant S. aureus, and PAA-MoSe2 displays species-specific antimicrobial activ-ity against S. aureus without external stimuli. Mechanistic studies have revealed that the redox reactions of PAA-WSe2 nanosheets mediated by lipoteichoic acid of gram-positive bacteria to produce a more active element Se4+ are responsible for their narrow-spectrum bactericidal activity against gram-positive bacteria. Finally, the PAA-WSe2 nanosheets effectively eradicate the bacteria in S. aureus-infected mice, leading to excellent therapeutic efficacy in infected wounds. This strategy, based on narrow-spectrum transition metal dichalcogenide antibiotics, can provide an alternative route for the effective treatment of various bacterial infections. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | Elsevier BV | - |
dc.title | Insights into the selective bactericidal activity of W(Mo)Se2 nanosheets for therapy of pathogenic bacterial infections | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Jong-Ho | - |
dc.identifier.doi | 10.1016/j.cej.2023.143727 | - |
dc.identifier.scopusid | 2-s2.0-85162269283 | - |
dc.identifier.wosid | 001013363900001 | - |
dc.identifier.bibliographicCitation | Chemical Engineering Journal, v.468, pp.1 - 11 | - |
dc.relation.isPartOf | Chemical Engineering Journal | - |
dc.citation.title | Chemical Engineering Journal | - |
dc.citation.volume | 468 | - |
dc.citation.startPage | 1 | - |
dc.citation.endPage | 11 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Engineering | - |
dc.relation.journalWebOfScienceCategory | Engineering, Environmental | - |
dc.relation.journalWebOfScienceCategory | Engineering, Chemical | - |
dc.subject.keywordPlus | HIGH ANTIBACTERIAL ACTIVITY | - |
dc.subject.keywordPlus | ASSISTED EXFOLIATION | - |
dc.subject.keywordPlus | TRANSITION | - |
dc.subject.keywordPlus | MOS2 | - |
dc.subject.keywordPlus | RESISTANCE | - |
dc.subject.keywordPlus | DICHALCOGENIDES | - |
dc.subject.keywordPlus | CHITOSAN | - |
dc.subject.keywordAuthor | Antimicrobial | - |
dc.subject.keywordAuthor | Bacterial infection | - |
dc.subject.keywordAuthor | Narrow-spectrum bactericidal activity | - |
dc.subject.keywordAuthor | Multidrug resistance | - |
dc.subject.keywordAuthor | TMD nanosheet antibiotics | - |
dc.identifier.url | https://www.sciencedirect.com/science/article/pii/S1385894723024580 | - |
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