Combined endoscopic and radiologic healing is associated with a better prognosis than endoscopic healing only in patients with Crohn's disease receiving anti-TNF therapy
DC Field | Value | Language |
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dc.contributor.author | Oh, Kyunghwan | - |
dc.contributor.author | Oh, Eun Hye | - |
dc.contributor.author | Noh, Soo Min | - |
dc.contributor.author | Park, Seong Ho | - |
dc.contributor.author | Kim, Nayoung | - |
dc.contributor.author | Hwang, Sung Wook | - |
dc.contributor.author | Park, Sang Hyoung | - |
dc.contributor.author | Yang, Dong-Hoon | - |
dc.contributor.author | Byeon, Jeong-Sik | - |
dc.contributor.author | Myung, Seung-Jae | - |
dc.contributor.author | Yang, Suk-Kyun | - |
dc.contributor.author | Ye, Byong Duk | - |
dc.date.accessioned | 2023-08-16T07:48:27Z | - |
dc.date.available | 2023-08-16T07:48:27Z | - |
dc.date.created | 2023-07-21 | - |
dc.date.issued | 2022-01 | - |
dc.identifier.issn | 2155384X | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/189138 | - |
dc.description.abstract | INTRODUCTION: Although endoscopic healing (EH) is recommended as the therapeutic goal in patients with Crohn's disease (CD), combined EH and radiologic healing (RH) could be a more ideal therapeutic goal considering the transmural nature of CD. We compared the prognosis of patients with CD who achieved EH, RH, both EH and RH (deep healing; DH), or no healing under treatment with anti-tumor necrosis factor (TNF) agents. METHODS: We analyzed 392 patients with CD who received anti-TNF treatment for more than 1 year and evaluated with CT enterography or magnetic resonance enterography together with colonoscopy within 3 months between July 2017 and December 2018. Major outcomes (anti-TNF dose intensification, switch to other biologics, CD-related bowel resection, and hospitalization) were compared according to the EH and RH status. RESULTS: During the follow-up (median 18 months; interquartile range, 15-21), the DH group showed a better rate of major outcome-free survival compared with other groups (P < 0.001). In multivariable analysis, elevated C-reactive protein (adjusted hazard ratio [aHR], 2.166; 95% confidence interval [CI], 1.508-3.110; P < 0.001), EH-only (aHR, 3.903; 95% CI, 1.635-9.315; P = 0.002), RH-only (aHR, 3.843; 95% CI, 1.545-9.558; P = 0.004), and no healing (aHR, 8.844; 95% CI, 4.268-18.323; P < 0.001) were associated with increased risks of major outcomes. DISCUSSION: Patients with CD who achieved DH under anti-TNF therapy showed a better prognosis compared with those who only achieved EH. The possibility of DH being used as a new therapeutic target for patients with CD should be investigated in further studies. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | LIPPINCOTT WILLIAMS & WILKINS | - |
dc.title | Combined endoscopic and radiologic healing is associated with a better prognosis than endoscopic healing only in patients with Crohn's disease receiving anti-TNF therapy | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Oh, Eun Hye | - |
dc.identifier.doi | 10.14309/ctg.0000000000000442 | - |
dc.identifier.scopusid | 2-s2.0-85124438061 | - |
dc.identifier.wosid | 000751955300019 | - |
dc.identifier.bibliographicCitation | CLINICAL AND TRANSLATIONAL GASTROENTEROLOGY, v.13, no.1, pp.1 - 8 | - |
dc.relation.isPartOf | CLINICAL AND TRANSLATIONAL GASTROENTEROLOGY | - |
dc.citation.title | CLINICAL AND TRANSLATIONAL GASTROENTEROLOGY | - |
dc.citation.volume | 13 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 1 | - |
dc.citation.endPage | 8 | - |
dc.type.rims | ART | - |
dc.type.docType | 정기학술지(Article(Perspective Article포함)) | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Gastroenterology & Hepatology | - |
dc.relation.journalWebOfScienceCategory | Gastroenterology & Hepatology | - |
dc.subject.keywordAuthor | MAGNETIC-RESONANCE ENTEROGRAPHY | - |
dc.subject.keywordAuthor | SUSTAINED CLINICAL REMISSION | - |
dc.subject.keywordAuthor | INFLAMMATORY-BOWEL-DISEASE | - |
dc.subject.keywordAuthor | COMPUTED-TOMOGRAPHY | - |
dc.subject.keywordAuthor | MAINTENANCE TREATMENT | - |
dc.subject.keywordAuthor | DEEP REMISSION | - |
dc.subject.keywordAuthor | MUCOSAL | - |
dc.subject.keywordAuthor | PREDICTS | - |
dc.subject.keywordAuthor | PROGRESSION | - |
dc.subject.keywordAuthor | ADALIMUMAB | - |
dc.identifier.url | https://journals.lww.com/ctg/Fulltext/2022/01000/Combined_Endoscopic_and_Radiologic_Healing_Is.9.aspx | - |
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