Urinary transglutaminase 2 as a potent biomarker to predict interstitial fibrosis and tubular atrophy of kidney allograft during early posttransplant period in deceased donor kidney transplantation
DC Field | Value | Language |
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dc.contributor.author | Kim, Jee Yeon | - |
dc.contributor.author | Wee, Yu-Mee | - |
dc.contributor.author | Choi, Monica Young | - |
dc.contributor.author | Jung, Hey Rim | - |
dc.contributor.author | Choi, Ji Yoon | - |
dc.contributor.author | Kwon, Hyun Wook | - |
dc.contributor.author | Jung, Joo Hee | - |
dc.contributor.author | Cho, Yong Mee | - |
dc.contributor.author | Go, Heounjeong | - |
dc.contributor.author | Han, Minkyu | - |
dc.contributor.author | Kim, Young Hoon | - |
dc.contributor.author | Han, Duck Jong | - |
dc.contributor.author | Shin, Sung | - |
dc.date.accessioned | 2023-08-22T03:09:10Z | - |
dc.date.available | 2023-08-22T03:09:10Z | - |
dc.date.created | 2023-07-21 | - |
dc.date.issued | 2019-07 | - |
dc.identifier.issn | 2288-6575 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/189481 | - |
dc.description.abstract | Purpose: Transglutaminase type 2 [TG2] is an extracellular matrix crosslinking enzyme with a pivotal role in kidney fibrosis. We tested whether quantification of urinary TG2 may represent a noninvasive method to estimate the severity of kidney allograft fibrosis.,Methods: We prospectively collected urine specimens from 18 deceased donor kidney transplant recipients at 1-day, 7-day, 1-month, 3-month, and 6-month posttransplant. In addition, kidney allograft tissue specimens at 0-day and 6-month posttransplant were sampled to analyze the correlation of urinary TG2 and kidney allograft fibrosis.,Results: Thirteen recipients had increased interstitial fibrosis and tubular atrophy (IFTA) scores at the 6-month protocol biopsy (IFTA group). The mean level of urinary TG2 in the IFTA group was higher compared to that of 5 other recipients without IFTA (no IFTA group). Conversely, the mean level of urinary syndecan-4 in the IFTA group was tower than levels in patients without IFTA. In the IFTA group, double immunofluorescent staining revealed that TG2 intensity was significantly upregulated and colocalizations of TG2/heparin sulfate proteoglycan and nuclear syndecan-4 were prominent, usually around tubular structures.,Conclusion: Urinary TG2 in early posttransplant periods is a potent biomarker for kidney allograft inflammation or fibrosis., | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | KOREAN SURGICAL SOCIETY | - |
dc.title | Urinary transglutaminase 2 as a potent biomarker to predict interstitial fibrosis and tubular atrophy of kidney allograft during early posttransplant period in deceased donor kidney transplantation | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Choi, Ji Yoon | - |
dc.identifier.doi | 10.4174/astr.2019.97.1.27 | - |
dc.identifier.scopusid | 2-s2.0-85069493661 | - |
dc.identifier.wosid | 000474248900005 | - |
dc.identifier.bibliographicCitation | ANNALS OF SURGICAL TREATMENT AND RESEARCH, v.97, no.1, pp.27 - 35 | - |
dc.relation.isPartOf | ANNALS OF SURGICAL TREATMENT AND RESEARCH | - |
dc.citation.title | ANNALS OF SURGICAL TREATMENT AND RESEARCH | - |
dc.citation.volume | 97 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 27 | - |
dc.citation.endPage | 35 | - |
dc.type.rims | ART | - |
dc.type.docType | 정기학술지(Article(Perspective Article포함)) | - |
dc.identifier.kciid | ART002474295 | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | Surgery | - |
dc.relation.journalWebOfScienceCategory | Surgery | - |
dc.subject.keywordPlus | TISSUE-TRANSGLUTAMINASE | - |
dc.subject.keywordPlus | INFLAMMATION | - |
dc.subject.keywordPlus | CONTRIBUTES | - |
dc.subject.keywordPlus | PROGRESSION | - |
dc.subject.keywordPlus | RECIPIENTS | - |
dc.subject.keywordPlus | REJECTION | - |
dc.subject.keywordPlus | COLLAGEN | - |
dc.subject.keywordPlus | RISK | - |
dc.subject.keywordAuthor | Biomarkers | - |
dc.subject.keywordAuthor | Transglutaminase 2 | - |
dc.subject.keywordAuthor | Kidney transplantation | - |
dc.identifier.url | https://astr.or.kr/DOIx.php?id=10.4174/astr.2019.97.1.27 | - |
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