Development of propolis extract-loaded nanoparticles with chitosan and hyaluronic acid for improving solubility and stability
DC Field | Value | Language |
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dc.contributor.author | Kim, Do Hee | - |
dc.contributor.author | Jeong, Eun Woo | - |
dc.contributor.author | Baek, Youjin | - |
dc.contributor.author | Lee, Hyeon Gyu | - |
dc.date.accessioned | 2023-09-04T05:30:02Z | - |
dc.date.available | 2023-09-04T05:30:02Z | - |
dc.date.created | 2023-05-03 | - |
dc.date.issued | 2023-05 | - |
dc.identifier.issn | 0023-6438 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/189588 | - |
dc.description.abstract | Propolis extract (PE) is a natural polyphenol with various biological activities; however, its application is limited due to low solubility and instability. To overcome these drawbacks, we encapsulated PE in nanoparticles (PE-loaded nanoparticles, PE-NP) using chitosan (CS) and hyaluronic acid (HA) as wall materials. We examined the physicochemical characteristics (size, polydispersity index, zeta potential, and entrapment efficiency) of PE-NP prepared with the various ratios of CS to HA and core to the wall material, and confirmed the optimal ratio for the formulation of PE-NP as 4:7 and 1:2, respectively. In addition, PE-NP significantly increased the solubility of PE by 2.43-fold compared to that of free PE (p < 0.05). Moreover, the retention rate of total flavonoid content (TFC) in PE-NP was significantly higher than that in free PE after the heat treatment (90 °C) for 24 h (p < 0.05). Furthermore, PE-NP showed significantly higher retention rates of TFC and DPPH radical scavenging effects than free PE after storage for 4 weeks at 30 and 50 °C (p < 0.05). In conclusion, these findings suggest that PE-NP may be a promising approach to enhance the solubility and stability of PE and could provide helpful information for expanding the application of PE. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER | - |
dc.title | Development of propolis extract-loaded nanoparticles with chitosan and hyaluronic acid for improving solubility and stability | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Lee, Hyeon Gyu | - |
dc.identifier.doi | 10.1016/j.lwt.2023.114738 | - |
dc.identifier.scopusid | 2-s2.0-85152591673 | - |
dc.identifier.wosid | 001041191000001 | - |
dc.identifier.bibliographicCitation | LWT-FOOD SCIENCE AND TECHNOLOGY, v.181, pp.1 - 8 | - |
dc.relation.isPartOf | LWT-FOOD SCIENCE AND TECHNOLOGY | - |
dc.citation.title | LWT-FOOD SCIENCE AND TECHNOLOGY | - |
dc.citation.volume | 181 | - |
dc.citation.startPage | 1 | - |
dc.citation.endPage | 8 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Food Science & Technology | - |
dc.relation.journalWebOfScienceCategory | Food Science & Technology | - |
dc.subject.keywordPlus | ANTIMICROBIAL ACTIVITY | - |
dc.subject.keywordPlus | ANTIOXIDANT ACTIVITY | - |
dc.subject.keywordPlus | CELLULAR UPTAKE | - |
dc.subject.keywordPlus | ENCAPSULATION | - |
dc.subject.keywordPlus | DELIVERY | - |
dc.subject.keywordPlus | RELEASE | - |
dc.subject.keywordPlus | PROTEIN | - |
dc.subject.keywordAuthor | Propolis extract | - |
dc.subject.keywordAuthor | Encapsulation | - |
dc.subject.keywordAuthor | Hyaluronic acid | - |
dc.subject.keywordAuthor | Solubility | - |
dc.subject.keywordAuthor | Stability | - |
dc.identifier.url | https://www.sciencedirect.com/science/article/pii/S0023643823003171?via%3Dihub | - |
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