원반모양홍반루푸스 탈모 환자의 더모스코피 소견과 치료 반응의 상관관계에 관한 후향적 연구

Abstract

Background: Discoid lupus erythematosus (DLE) with alopecia of the scalp can result in permanent hair loss. Therefore,it is important to evaluate skin lesions and establish appropriate treatment plans for scalp DLE with alopecia. Objective: We aimed to investigate the dermoscopic features of scalp DLE with alopecia and to determine thecorrelation between dermoscopic findings and treatment efficacy. Methods: Thirty-one patients histopathologically diagnosed with scalp DLE and alopecia were included. Wereviewed clinical photographs and dermoscopic findings of the patients and evaluated their treatment responses. Results: The most frequent dermoscopic features of DLE with alopecia were follicular keratotic plugs (96.8%), whitescales (71.0%), telangiectatic vessels (67.7%), and pigmentation (64.5%); followed by absent follicular openings (48.4%),white structureless areas (35.5%), follicular red dots (16.1%), and perifollicular whitish halo (12.9%). After at least 6months of treatment, hair regrowth was observed in 22 patients (71.0%). Dermoscopic findings showed that whitestructureless areas, perifollicular whitish halo, absent follicular openings (especially when the alopecic patch involved ＞25%of the scalp), and moderate to severe telangiectatic vessels were associated with absence of hair regrowth. Conclusion: Dermoscopy is a promising tool for evaluating lesions and predicting therapeutic outcomes in scalpDLE with alopecia. It may contribute to the establishment of appropriate treatment plan by determining whether hairloss is reversible.