Temporal association between the age-specific incidence of Guillain-Barré syndrome and SARS-CoV-2 vaccination in Republic of Korea: a nationwide time-series correlation study
DC Field | Value | Language |
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dc.contributor.author | Lee, Hyunju | - |
dc.contributor.author | Kwon, Donghyok | - |
dc.contributor.author | Park, Seoncheol | - |
dc.contributor.author | Park, Seung Ri | - |
dc.contributor.author | Chung, Darda | - |
dc.contributor.author | Ha, Jongmok | - |
dc.date.accessioned | 2023-09-04T07:07:06Z | - |
dc.date.available | 2023-09-04T07:07:06Z | - |
dc.date.created | 2023-08-01 | - |
dc.date.issued | 2023-06 | - |
dc.identifier.issn | 2210-9099 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/189654 | - |
dc.description.abstract | Objectives: The incidence of Guillain-Barré syndrome (GBS) changed significantly during the coronavirus disease 2019 (COVID-19) pandemic. Emerging reports suggest that viral vector-based vaccines may be associated with an elevated risk of GBS. Methods: In this nationwide time-series correlation study, we examined the age-specific incidence of GBS from January 2011 to August 2022, as well as data on severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccinations and infections from February 2021 to August 2022. We compared the forecasted estimates of age-specific GBS incidence, using the pre-SARS-CoV-2 period as a benchmark, with the actual incidence observed during the post-vaccination period of the pandemic. Furthermore, we assessed the temporal association between GBS, SARS-CoV-2 vaccinations, and COVID-19 for different age groups. Results: In the age group of 60 and older, the rate ratio was significantly elevated during June-August and November 2021. A significant, strong positive association was observed between viral vector-based vaccines and GBS incidence trends in this age group (r=0.52, p=0.022). For the 30 to 59 years age group, the rate ratio was notably high in September 2021. A statistically significant, strong positive association was found between mRNA-based vaccines and GBS incidence in this age group (r=0.61, p=0.006). Conclusion: Viral vector-based SARS-CoV-2 vaccines were found to be temporally associated with an increased risk of GBS, particularly in older adults. To minimize age-specific and biological mechanism-specific adverse events, future vaccination campaigns should adopt a more personalized approach, such as recommending homologous mRNA-based SARS-CoV-2 vaccines for older adults to reduce the heightened risk of GBS. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | KOREA DISEASE CONTROL & PREVENTION AGENCY | - |
dc.title | Temporal association between the age-specific incidence of Guillain-Barré syndrome and SARS-CoV-2 vaccination in Republic of Korea: a nationwide time-series correlation study | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Park, Seoncheol | - |
dc.identifier.doi | 10.24171/j.phrp.2023.0050 | - |
dc.identifier.scopusid | 2-s2.0-85165603985 | - |
dc.identifier.wosid | 001021435300010 | - |
dc.identifier.bibliographicCitation | OSONG PUBLIC HEALTH AND RESEARCH PERSPECTIVES, v.14, no.3, pp.224 - 231 | - |
dc.relation.isPartOf | OSONG PUBLIC HEALTH AND RESEARCH PERSPECTIVES | - |
dc.citation.title | OSONG PUBLIC HEALTH AND RESEARCH PERSPECTIVES | - |
dc.citation.volume | 14 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 224 | - |
dc.citation.endPage | 231 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART002972034 | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | Public, Environmental & Occupational Health | - |
dc.relation.journalWebOfScienceCategory | Public, Environmental & Occupational Health | - |
dc.subject.keywordPlus | COVID-19 | - |
dc.subject.keywordAuthor | COVID-19 | - |
dc.subject.keywordAuthor | COVID-19 vaccines | - |
dc.subject.keywordAuthor | Guillain-Barre syndrome | - |
dc.subject.keywordAuthor | SARS-CoV-2 | - |
dc.identifier.url | https://ophrp.org/journal/view.php?doi=10.24171/j.phrp.2023.0050 | - |
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